The Expressed Genome in Cardiovascular Diseases and Stroke: Refinement, Diagnosis, and Prediction: A Scientific Statement From the American Heart Association.
Publication
, Journal Article
Musunuru, K; Ingelsson, E; Fornage, M; Liu, P; Murphy, AM; Newby, LK; Newton-Cheh, C; Perez, MV; Voora, D; Woo, D; and Stroke Council ...
Published in: Circ Cardiovasc Genet
August 2017
There have been major advances in our knowledge of the contribution of DNA sequence variations to cardiovascular disease and stroke. However, the inner workings of the body reflect the complex interplay of factors beyond the DNA sequence, including epigenetic modifications, RNA transcripts, proteins, and metabolites, which together can be considered the "expressed genome." The emergence of high-throughput technologies, including epigenomics, transcriptomics, proteomics, and metabolomics, is now making it possible to address the contributions of the expressed genome to cardiovascular disorders. This statement describes how the expressed genome can currently and, in the future, potentially be used to diagnose diseases and to predict who will develop diseases such as coronary artery disease, stroke, heart failure, and arrhythmias.
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Published In
Circ Cardiovasc Genet
DOI
EISSN
1942-3268
Publication Date
August 2017
Volume
10
Issue
4
Location
United States
Related Subject Headings
- United States
- Stroke
- Proteomics
- Metabolomics
- Humans
- Genome, Human
- Epigenomics
- Cardiovascular System & Hematology
- Cardiovascular Diseases
- Biomarkers
Citation
APA
Chicago
ICMJE
MLA
NLM
Musunuru, K., Ingelsson, E., Fornage, M., Liu, P., Murphy, A. M., Newby, L. K., … American Heart Association Committee on Molecular Determinants of Cardiovascular Health of the Council on Functional Genomics and Translational Biology and Council on Epidemiology and Prevention; Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; Council on Cardiovascular Surgery and Anesthesia; Council on Clinical Cardiology; and Stroke Council. (2017). The Expressed Genome in Cardiovascular Diseases and Stroke: Refinement, Diagnosis, and Prediction: A Scientific Statement From the American Heart Association. Circ Cardiovasc Genet, 10(4). https://doi.org/10.1161/HCG.0000000000000037
Musunuru, Kiran, Erik Ingelsson, Myriam Fornage, Peter Liu, Anne M. Murphy, L Kristin Newby, Christopher Newton-Cheh, et al. “The Expressed Genome in Cardiovascular Diseases and Stroke: Refinement, Diagnosis, and Prediction: A Scientific Statement From the American Heart Association.” Circ Cardiovasc Genet 10, no. 4 (August 2017). https://doi.org/10.1161/HCG.0000000000000037.
Musunuru K, Ingelsson E, Fornage M, Liu P, Murphy AM, Newby LK, et al. The Expressed Genome in Cardiovascular Diseases and Stroke: Refinement, Diagnosis, and Prediction: A Scientific Statement From the American Heart Association. Circ Cardiovasc Genet. 2017 Aug;10(4).
Musunuru, Kiran, et al. “The Expressed Genome in Cardiovascular Diseases and Stroke: Refinement, Diagnosis, and Prediction: A Scientific Statement From the American Heart Association.” Circ Cardiovasc Genet, vol. 10, no. 4, Aug. 2017. Pubmed, doi:10.1161/HCG.0000000000000037.
Musunuru K, Ingelsson E, Fornage M, Liu P, Murphy AM, Newby LK, Newton-Cheh C, Perez MV, Voora D, Woo D, American Heart Association Committee on Molecular Determinants of Cardiovascular Health of the Council on Functional Genomics and Translational Biology and Council on Epidemiology and Prevention; Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; Council on Cardiovascular Surgery and Anesthesia; Council on Clinical Cardiology; and Stroke Council. The Expressed Genome in Cardiovascular Diseases and Stroke: Refinement, Diagnosis, and Prediction: A Scientific Statement From the American Heart Association. Circ Cardiovasc Genet. 2017 Aug;10(4).
Published In
Circ Cardiovasc Genet
DOI
EISSN
1942-3268
Publication Date
August 2017
Volume
10
Issue
4
Location
United States
Related Subject Headings
- United States
- Stroke
- Proteomics
- Metabolomics
- Humans
- Genome, Human
- Epigenomics
- Cardiovascular System & Hematology
- Cardiovascular Diseases
- Biomarkers