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Human Leukocyte Antigen Sensitization in Solid Organ Transplantation: A Primer on Terminology, Testing, and Clinical Significance for the Apheresis Practitioner.

Publication ,  Journal Article
Abbes, S; Metjian, A; Gray, A; Martinu, T; Snyder, L; Chen, D-F; Ellis, M; Arepally, GM; Onwuemene, O
Published in: Ther Apher Dial
October 2017

The human leukocyte antigen (HLA) system is an important immunologic barrier that must be considered for successful solid organ transplantation. Formation of donor-specific HLA antibodies in solid organ transplantation is an important cause of allograft injury and may contribute to recipient morbidity and mortality. Therapeutic plasma exchange is often requested to lower HLA antibody levels prior to or after transplantation and for management of HLA antibodies in the context of organ rejection. In this review, we summarize the current terminology, laboratory testing, and clinical significance of HLA sensitization in the solid organ transplant population. Furthermore, to illustrate applications of HLA testing in clinical practice, we summarize our own lung and kidney institutional protocols for managing HLA antibodies in the peri-transplant setting.

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Published In

Ther Apher Dial

DOI

EISSN

1744-9987

Publication Date

October 2017

Volume

21

Issue

5

Start / End Page

441 / 450

Location

Australia

Related Subject Headings

  • Urology & Nephrology
  • Tissue Donors
  • Terminology as Topic
  • Plasma Exchange
  • Organ Transplantation
  • Lung Transplantation
  • Kidney Transplantation
  • Humans
  • HLA Antigens
  • Graft Rejection
 

Citation

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Abbes, S., Metjian, A., Gray, A., Martinu, T., Snyder, L., Chen, D.-F., … Onwuemene, O. (2017). Human Leukocyte Antigen Sensitization in Solid Organ Transplantation: A Primer on Terminology, Testing, and Clinical Significance for the Apheresis Practitioner. Ther Apher Dial, 21(5), 441–450. https://doi.org/10.1111/1744-9987.12570
Abbes, Sarah, Ara Metjian, Alice Gray, Tereza Martinu, Laurie Snyder, Dong-Feng Chen, Matthew Ellis, Gowthami M. Arepally, and Oluwatoyosi Onwuemene. “Human Leukocyte Antigen Sensitization in Solid Organ Transplantation: A Primer on Terminology, Testing, and Clinical Significance for the Apheresis Practitioner.Ther Apher Dial 21, no. 5 (October 2017): 441–50. https://doi.org/10.1111/1744-9987.12570.
Abbes S, Metjian A, Gray A, Martinu T, Snyder L, Chen D-F, et al. Human Leukocyte Antigen Sensitization in Solid Organ Transplantation: A Primer on Terminology, Testing, and Clinical Significance for the Apheresis Practitioner. Ther Apher Dial. 2017 Oct;21(5):441–50.
Abbes, Sarah, et al. “Human Leukocyte Antigen Sensitization in Solid Organ Transplantation: A Primer on Terminology, Testing, and Clinical Significance for the Apheresis Practitioner.Ther Apher Dial, vol. 21, no. 5, Oct. 2017, pp. 441–50. Pubmed, doi:10.1111/1744-9987.12570.
Abbes S, Metjian A, Gray A, Martinu T, Snyder L, Chen D-F, Ellis M, Arepally GM, Onwuemene O. Human Leukocyte Antigen Sensitization in Solid Organ Transplantation: A Primer on Terminology, Testing, and Clinical Significance for the Apheresis Practitioner. Ther Apher Dial. 2017 Oct;21(5):441–450.
Journal cover image

Published In

Ther Apher Dial

DOI

EISSN

1744-9987

Publication Date

October 2017

Volume

21

Issue

5

Start / End Page

441 / 450

Location

Australia

Related Subject Headings

  • Urology & Nephrology
  • Tissue Donors
  • Terminology as Topic
  • Plasma Exchange
  • Organ Transplantation
  • Lung Transplantation
  • Kidney Transplantation
  • Humans
  • HLA Antigens
  • Graft Rejection