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Metabolic control by sirtuins and other enzymes that sense NAD+, NADH, or their ratio.

Publication ,  Journal Article
Anderson, KA; Madsen, AS; Olsen, CA; Hirschey, MD
Published in: Biochim Biophys Acta Bioenerg
December 2017

NAD+ is a dinucleotide cofactor with the potential to accept electrons in a variety of cellular reduction-oxidation (redox) reactions. In its reduced form, NADH is a ubiquitous cellular electron donor. NAD+, NADH, and the NAD+/NADH ratio have long been known to control the activity of several oxidoreductase enzymes. More recently, enzymes outside those participating directly in redox control have been identified that sense these dinucleotides, including the sirtuin family of NAD+-dependent protein deacylases. In this review, we highlight examples of non-redox enzymes that are controlled by NAD+, NADH, or NAD+/NADH. In particular, we focus on the sirtuin family and assess the current evidence that the sirtuin enzymes sense these dinucleotides and discuss the biological conditions under which this might occur; we conclude that sirtuins sense NAD+, but neither NADH nor the ratio. Finally, we identify future studies that might be informative to further interrogate physiological and pathophysiological changes in NAD+ and NADH, as well as enzymes like sirtuins that sense and respond to redox changes in the cell.

Duke Scholars

Published In

Biochim Biophys Acta Bioenerg

DOI

ISSN

0005-2728

Publication Date

December 2017

Volume

1858

Issue

12

Start / End Page

991 / 998

Location

Netherlands

Related Subject Headings

  • Sirtuins
  • Oxidoreductases
  • Oxidation-Reduction
  • NAD
  • Electron Transport
  • Biophysics
  • Biochemical Phenomena
  • 3101 Biochemistry and cell biology
  • 0601 Biochemistry and Cell Biology
  • 0306 Physical Chemistry (incl. Structural)
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Anderson, K. A., Madsen, A. S., Olsen, C. A., & Hirschey, M. D. (2017). Metabolic control by sirtuins and other enzymes that sense NAD+, NADH, or their ratio. Biochim Biophys Acta Bioenerg, 1858(12), 991–998. https://doi.org/10.1016/j.bbabio.2017.09.005
Journal cover image

Published In

Biochim Biophys Acta Bioenerg

DOI

ISSN

0005-2728

Publication Date

December 2017

Volume

1858

Issue

12

Start / End Page

991 / 998

Location

Netherlands

Related Subject Headings

  • Sirtuins
  • Oxidoreductases
  • Oxidation-Reduction
  • NAD
  • Electron Transport
  • Biophysics
  • Biochemical Phenomena
  • 3101 Biochemistry and cell biology
  • 0601 Biochemistry and Cell Biology
  • 0306 Physical Chemistry (incl. Structural)