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Low and High Birth Weights Are Risk Factors for Nonalcoholic Fatty Liver Disease in Children.

Publication ,  Journal Article
Newton, KP; Feldman, HS; Chambers, CD; Wilson, L; Behling, C; Clark, JM; Molleston, JP; Chalasani, N; Sanyal, AJ; Fishbein, MH; Lavine, JE ...
Published in: J Pediatr
August 2017

OBJECTIVES: To examine the distribution of birth weight in children with nonalcoholic fatty liver disease (NAFLD) compared with the general US population, and to investigate the relationship between birth weight and severity of NAFLD. STUDY DESIGN: A multicenter, cross-sectional study of children with biopsy-proven NAFLD enrolled in the Nonalcoholic Steatohepatitis Clinical Research Network Database. Birth weight was categorized as low birth weight (LBW), normal birth weight (NBW), or high birth weight (HBW) and compared with the birth weight distribution in the general US population. The severity of liver histology was assessed by birth weight category. RESULTS: Children with NAFLD (n = 538) had overrepresentation of both LBW and HBW compared with the general US population (LBW, 9.3%; NBW, 75.8%; HBW, 14.9% vs LBW, 6.1%; NBW, 83.5%; HBW 10.5%; P < .0001). Children with HBW had significantly greater odds of having more severe steatosis (OR, 1.82, 95% CI. 1.15-2.88) and nonalcoholic steatohepatitis (OR, 2.03; 95% CI, 1.21-3.40) compared with children with NBW. In addition, children with NAFLD and LBW had significantly greater odds of having advanced fibrosis (OR, 2.23; 95% CI, 1.08-4.62). CONCLUSION: Birth weight involves maternal and in utero factors that may have long-lasting consequences. Children with both LBW and HBW may be at increased risk for developing NAFLD. Among children with NAFLD, those with LBW or HBW appear to be at increased risk for more severe disease.

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Published In

J Pediatr

DOI

EISSN

1097-6833

Publication Date

August 2017

Volume

187

Start / End Page

141 / 146.e1

Location

United States

Related Subject Headings

  • United States
  • Risk Factors
  • Pediatrics
  • Non-alcoholic Fatty Liver Disease
  • Male
  • Liver
  • Infant, Postmature
  • Infant, Low Birth Weight
  • Humans
  • Female
 

Citation

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Newton, K. P., Feldman, H. S., Chambers, C. D., Wilson, L., Behling, C., Clark, J. M., … Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN), . (2017). Low and High Birth Weights Are Risk Factors for Nonalcoholic Fatty Liver Disease in Children. J Pediatr, 187, 141-146.e1. https://doi.org/10.1016/j.jpeds.2017.03.007
Newton, Kimberly P., Haruna S. Feldman, Christina D. Chambers, Laura Wilson, Cynthia Behling, Jeanne M. Clark, Jean P. Molleston, et al. “Low and High Birth Weights Are Risk Factors for Nonalcoholic Fatty Liver Disease in Children.J Pediatr 187 (August 2017): 141-146.e1. https://doi.org/10.1016/j.jpeds.2017.03.007.
Newton KP, Feldman HS, Chambers CD, Wilson L, Behling C, Clark JM, et al. Low and High Birth Weights Are Risk Factors for Nonalcoholic Fatty Liver Disease in Children. J Pediatr. 2017 Aug;187:141-146.e1.
Newton, Kimberly P., et al. “Low and High Birth Weights Are Risk Factors for Nonalcoholic Fatty Liver Disease in Children.J Pediatr, vol. 187, Aug. 2017, pp. 141-146.e1. Pubmed, doi:10.1016/j.jpeds.2017.03.007.
Newton KP, Feldman HS, Chambers CD, Wilson L, Behling C, Clark JM, Molleston JP, Chalasani N, Sanyal AJ, Fishbein MH, Lavine JE, Schwimmer JB, Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN). Low and High Birth Weights Are Risk Factors for Nonalcoholic Fatty Liver Disease in Children. J Pediatr. 2017 Aug;187:141-146.e1.
Journal cover image

Published In

J Pediatr

DOI

EISSN

1097-6833

Publication Date

August 2017

Volume

187

Start / End Page

141 / 146.e1

Location

United States

Related Subject Headings

  • United States
  • Risk Factors
  • Pediatrics
  • Non-alcoholic Fatty Liver Disease
  • Male
  • Liver
  • Infant, Postmature
  • Infant, Low Birth Weight
  • Humans
  • Female