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Prevalence, healthcare resource utilization and overall burden of fungal meningitis in the United States.

Publication ,  Journal Article
Charalambous, LT; Premji, A; Tybout, C; Hunt, A; Cutshaw, D; Elsamadicy, AA; Yang, S; Xie, J; Giamberardino, C; Pagadala, P; Perfect, JR; Lad, SP
Published in: J Med Microbiol
February 2018

PURPOSE: Previous epidemiological and cost studies of fungal meningitis have largely focused on single pathogens, leading to a poor understanding of the disease in general. We studied the largest and most diverse group of fungal meningitis patients to date, over the longest follow-up period, to examine the broad impact on resource utilization within the United States. METHODOLOGY: The Truven Health Analytics MarketScan database was used to identify patients with a fungal meningitis diagnosis in the United States between 2000 and 2012. Patients with a primary diagnosis of cryptococcal, Coccidioides, Histoplasma, or Candida meningitis were included in the analysis. Data concerning healthcare resource utilization, prevalence and length of stay were collected for up to 5 years following the original diagnosis. RESULTS: Cryptococcal meningitis was the most prevalent type of fungal meningitis (70.1 % of cases over the duration of the study), followed by coccidioidomycosis (16.4 %), histoplasmosis (6.0 %) and candidiasis (7.6 %). Cryptococcal meningitis and candidiasis patients accrued the largest average charges ($103 236 and $103 803, respectively) and spent the most time in the hospital on average (70.6 and 79 days). Coccidioidomycosis and histoplasmosis patients also accrued substantial charges and time in the hospital ($82 439, 48.1 days; $78 609, 49.8 days, respectively). CONCLUSION: Our study characterizes the largest longitudinal cohort of fungal meningitis in the United States. Importantly, the health economic impact and long-term morbidity from these infections are quantified and reviewed. The healthcare resource utilization of fungal meningitis patients in the United States is substantial.

Duke Scholars

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Published In

J Med Microbiol

DOI

EISSN

1473-5644

Publication Date

February 2018

Volume

67

Issue

2

Start / End Page

215 / 227

Location

England

Related Subject Headings

  • Young Adult
  • United States
  • Prevalence
  • Middle Aged
  • Microbiology
  • Meningitis, Fungal
  • Meningitis, Cryptococcal
  • Male
  • Humans
  • Histoplasmosis
 

Citation

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Charalambous, L. T., Premji, A., Tybout, C., Hunt, A., Cutshaw, D., Elsamadicy, A. A., … Lad, S. P. (2018). Prevalence, healthcare resource utilization and overall burden of fungal meningitis in the United States. J Med Microbiol, 67(2), 215–227. https://doi.org/10.1099/jmm.0.000656
Charalambous, Lefko T., Alykhan Premji, Caroline Tybout, Anastasia Hunt, Drew Cutshaw, Aladine A. Elsamadicy, Siyun Yang, et al. “Prevalence, healthcare resource utilization and overall burden of fungal meningitis in the United States.J Med Microbiol 67, no. 2 (February 2018): 215–27. https://doi.org/10.1099/jmm.0.000656.
Charalambous LT, Premji A, Tybout C, Hunt A, Cutshaw D, Elsamadicy AA, et al. Prevalence, healthcare resource utilization and overall burden of fungal meningitis in the United States. J Med Microbiol. 2018 Feb;67(2):215–27.
Charalambous, Lefko T., et al. “Prevalence, healthcare resource utilization and overall burden of fungal meningitis in the United States.J Med Microbiol, vol. 67, no. 2, Feb. 2018, pp. 215–27. Pubmed, doi:10.1099/jmm.0.000656.
Charalambous LT, Premji A, Tybout C, Hunt A, Cutshaw D, Elsamadicy AA, Yang S, Xie J, Giamberardino C, Pagadala P, Perfect JR, Lad SP. Prevalence, healthcare resource utilization and overall burden of fungal meningitis in the United States. J Med Microbiol. 2018 Feb;67(2):215–227.

Published In

J Med Microbiol

DOI

EISSN

1473-5644

Publication Date

February 2018

Volume

67

Issue

2

Start / End Page

215 / 227

Location

England

Related Subject Headings

  • Young Adult
  • United States
  • Prevalence
  • Middle Aged
  • Microbiology
  • Meningitis, Fungal
  • Meningitis, Cryptococcal
  • Male
  • Humans
  • Histoplasmosis