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Sub-anesthetic doses of ketamine attenuate nicotine self-administration in rats.

Publication ,  Journal Article
Rezvani, AH; Tizabi, Y; Slade, S; Getachew, B; Levin, ED
Published in: Neurosci Lett
March 6, 2018

Smoking cessation strategies are of prime medical importance. Despite availability of various pharmacological agents in combating addiction to nicotine, more effective medications are needed. Based on recent findings, the glutamatergic system in the brain may provide novel targets. Here, we evaluated the effects of acute administration of sub-anesthetic doses of ketamine, an NMDA receptor antagonist, in both male and female Sprague-Dawley rats trained to self-administer nicotine. Animals were injected subcutaneously with 5, 7.5 and 10 mg/kg ketamine or saline and the effects on the number of intravenous nicotine infusions during a 45 min session was measured. Ketamine treatment significantly reduced nicotine self-administration in a dose-dependent manner. Moreover, a differential sensitivity between the sexes was observed as male rats responded to a lower dose of ketamine and with higher magnitude of effect than female rats. It is concluded that glutamatergic receptor manipulations may offer a novel and potentially sex-dependent intervention in nicotine addiction.

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Published In

Neurosci Lett

DOI

EISSN

1872-7972

Publication Date

March 6, 2018

Volume

668

Start / End Page

98 / 102

Location

Ireland

Related Subject Headings

  • Tobacco Use Disorder
  • Self Administration
  • Receptors, N-Methyl-D-Aspartate
  • Rats, Sprague-Dawley
  • Rats
  • Nicotine
  • Male
  • Ketamine
  • Female
  • Excitatory Amino Acid Antagonists
 

Citation

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Rezvani, A. H., Tizabi, Y., Slade, S., Getachew, B., & Levin, E. D. (2018). Sub-anesthetic doses of ketamine attenuate nicotine self-administration in rats. Neurosci Lett, 668, 98–102. https://doi.org/10.1016/j.neulet.2018.01.022
Rezvani, Amir H., Yousef Tizabi, Susan Slade, Bruk Getachew, and Edward D. Levin. “Sub-anesthetic doses of ketamine attenuate nicotine self-administration in rats.Neurosci Lett 668 (March 6, 2018): 98–102. https://doi.org/10.1016/j.neulet.2018.01.022.
Rezvani AH, Tizabi Y, Slade S, Getachew B, Levin ED. Sub-anesthetic doses of ketamine attenuate nicotine self-administration in rats. Neurosci Lett. 2018 Mar 6;668:98–102.
Rezvani, Amir H., et al. “Sub-anesthetic doses of ketamine attenuate nicotine self-administration in rats.Neurosci Lett, vol. 668, Mar. 2018, pp. 98–102. Pubmed, doi:10.1016/j.neulet.2018.01.022.
Rezvani AH, Tizabi Y, Slade S, Getachew B, Levin ED. Sub-anesthetic doses of ketamine attenuate nicotine self-administration in rats. Neurosci Lett. 2018 Mar 6;668:98–102.
Journal cover image

Published In

Neurosci Lett

DOI

EISSN

1872-7972

Publication Date

March 6, 2018

Volume

668

Start / End Page

98 / 102

Location

Ireland

Related Subject Headings

  • Tobacco Use Disorder
  • Self Administration
  • Receptors, N-Methyl-D-Aspartate
  • Rats, Sprague-Dawley
  • Rats
  • Nicotine
  • Male
  • Ketamine
  • Female
  • Excitatory Amino Acid Antagonists