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Glioma through the looking GLASS: molecular evolution of diffuse gliomas and the Glioma Longitudinal Analysis Consortium.

Publication ,  Journal Article
GLASS Consortium,
Published in: Neuro Oncol
June 18, 2018

Adult diffuse gliomas are a diverse group of brain neoplasms that inflict a high emotional toll on patients and their families. The Cancer Genome Atlas and similar projects have provided a comprehensive understanding of the somatic alterations and molecular subtypes of glioma at diagnosis. However, gliomas undergo significant cellular and molecular evolution during disease progression. We review the current knowledge on the genomic and epigenetic abnormalities in primary tumors and after disease recurrence, highlight the gaps in the literature, and elaborate on the need for a new multi-institutional effort to bridge these knowledge gaps and how the Glioma Longitudinal Analysis Consortium (GLASS) aims to systemically catalog the longitudinal changes in gliomas. The GLASS initiative will provide essential insights into the evolution of glioma toward a lethal phenotype, with the potential to reveal targetable vulnerabilities and, ultimately, improved outcomes for a patient population in need.

Duke Scholars

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Published In

Neuro Oncol

DOI

EISSN

1523-5866

Publication Date

June 18, 2018

Volume

20

Issue

7

Start / End Page

873 / 884

Location

England

Related Subject Headings

  • Oncology & Carcinogenesis
  • Longitudinal Studies
  • Humans
  • Glioma
  • Genomics
  • Evolution, Molecular
  • Brain Neoplasms
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
  • 1109 Neurosciences
 

Citation

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Chicago
ICMJE
MLA
NLM
GLASS Consortium, . (2018). Glioma through the looking GLASS: molecular evolution of diffuse gliomas and the Glioma Longitudinal Analysis Consortium. Neuro Oncol, 20(7), 873–884. https://doi.org/10.1093/neuonc/noy020
GLASS Consortium, Junfeng. “Glioma through the looking GLASS: molecular evolution of diffuse gliomas and the Glioma Longitudinal Analysis Consortium.Neuro Oncol 20, no. 7 (June 18, 2018): 873–84. https://doi.org/10.1093/neuonc/noy020.
GLASS Consortium, Junfeng. “Glioma through the looking GLASS: molecular evolution of diffuse gliomas and the Glioma Longitudinal Analysis Consortium.Neuro Oncol, vol. 20, no. 7, June 2018, pp. 873–84. Pubmed, doi:10.1093/neuonc/noy020.
Journal cover image

Published In

Neuro Oncol

DOI

EISSN

1523-5866

Publication Date

June 18, 2018

Volume

20

Issue

7

Start / End Page

873 / 884

Location

England

Related Subject Headings

  • Oncology & Carcinogenesis
  • Longitudinal Studies
  • Humans
  • Glioma
  • Genomics
  • Evolution, Molecular
  • Brain Neoplasms
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
  • 1109 Neurosciences