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The Role of the Immune Cells in Fracture Healing.

Publication ,  Journal Article
Baht, GS; Vi, L; Alman, BA
Published in: Curr Osteoporos Rep
April 2018

PURPOSE OF REVIEW: Bone fracture healing is a complex physiological process relying on numerous cell types and signals. Inflammatory factors secreted by immune cells help to control recruitment, proliferation, differentiation, and activation of hematopoietic and mesenchymal cells. Within this review we will discuss the functional role of immune cells as it pertains to bone fracture healing. In doing so, we will outline the cytokines secreted and their effects within the healing fracture callus. RECENT FINDINGS: Macrophages have been found to play an important role in fracture healing. These immune cells signal to other cells of the fracture callus, modulating bone healing. Cytokines and cellular signals within fracture healing continue to be studied. The findings from this work have helped to reinforce the importance of osteoimmunity in bone fracture healing. Owing to these efforts, immunomodulation is emerging as a potential therapeutic target to improve bone fracture healing.

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Published In

Curr Osteoporos Rep

DOI

EISSN

1544-2241

Publication Date

April 2018

Volume

16

Issue

2

Start / End Page

138 / 145

Location

United States

Related Subject Headings

  • Mesenchymal Stem Cells
  • Macrophages
  • Humans
  • Hematopoietic Stem Cells
  • Fracture Healing
  • Endocrinology & Metabolism
  • Cytokines
  • Cell Proliferation
  • Cell Differentiation
  • Bony Callus
 

Citation

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Baht, G. S., Vi, L., & Alman, B. A. (2018). The Role of the Immune Cells in Fracture Healing. Curr Osteoporos Rep, 16(2), 138–145. https://doi.org/10.1007/s11914-018-0423-2
Baht, Gurpreet S., Linda Vi, and Benjamin A. Alman. “The Role of the Immune Cells in Fracture Healing.Curr Osteoporos Rep 16, no. 2 (April 2018): 138–45. https://doi.org/10.1007/s11914-018-0423-2.
Baht GS, Vi L, Alman BA. The Role of the Immune Cells in Fracture Healing. Curr Osteoporos Rep. 2018 Apr;16(2):138–45.
Baht, Gurpreet S., et al. “The Role of the Immune Cells in Fracture Healing.Curr Osteoporos Rep, vol. 16, no. 2, Apr. 2018, pp. 138–45. Pubmed, doi:10.1007/s11914-018-0423-2.
Baht GS, Vi L, Alman BA. The Role of the Immune Cells in Fracture Healing. Curr Osteoporos Rep. 2018 Apr;16(2):138–145.
Journal cover image

Published In

Curr Osteoporos Rep

DOI

EISSN

1544-2241

Publication Date

April 2018

Volume

16

Issue

2

Start / End Page

138 / 145

Location

United States

Related Subject Headings

  • Mesenchymal Stem Cells
  • Macrophages
  • Humans
  • Hematopoietic Stem Cells
  • Fracture Healing
  • Endocrinology & Metabolism
  • Cytokines
  • Cell Proliferation
  • Cell Differentiation
  • Bony Callus