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Genomic Approaches to Posttraumatic Stress Disorder: The Psychiatric Genomic Consortium Initiative.

Publication ,  Journal Article
Nievergelt, CM; Ashley-Koch, AE; Dalvie, S; Hauser, MA; Morey, RA; Smith, AK; Uddin, M
Published in: Biol Psychiatry
May 15, 2018

Posttraumatic stress disorder (PTSD) after exposure to a traumatic event is a highly prevalent psychiatric disorder. Heritability estimates from twin studies as well as from recent molecular data (single nucleotide polymorphism-based heritability) indicate moderate to high heritability, yet robust genetic variants for PTSD have not yet been identified and the genetic architecture of this polygenic disorder remains largely unknown. To date, fewer than 10 large-scale genome-wide association studies of PTSD have been published, with findings that highlight the unique challenges for PTSD genomics, including a complex diagnostic entity with contingency of PTSD diagnosis on trauma exposure and the large genetic diversity of the study populations. The Psychiatric Genomics Consortium PTSD group has brought together more than 200 scientists with the goal to increase sample size for genome-wide association studies and other genomic analyses to sufficient numbers where robust discoveries of molecular signatures can be achieved. The sample currently includes more than 32,000 PTSD cases and 100,000 trauma-exposed control subjects, and collection is ongoing. The first results found a significant shared genetic risk of PTSD with other psychiatric disorders and sex-biased heritability estimates with higher heritability in female individuals compared with male individuals. This review describes the scope and current focus of the Psychiatric Genomics Consortium PTSD group and its expansion from the initial genome-wide association study group to nine working groups, including epigenetics, gene expression, imaging, and integrative systems biology. We further briefly outline recent findings and future directions of "omics"-based studies of PTSD, with the ultimate goal of elucidating the molecular architecture of this complex disorder to improve prevention and intervention strategies.

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Published In

Biol Psychiatry

DOI

EISSN

1873-2402

Publication Date

May 15, 2018

Volume

83

Issue

10

Start / End Page

831 / 839

Location

United States

Related Subject Headings

  • Stress Disorders, Post-Traumatic
  • Psychiatry
  • Humans
  • Genomics
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
  • Epigenomics
  • 52 Psychology
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
 

Citation

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Nievergelt, C. M., Ashley-Koch, A. E., Dalvie, S., Hauser, M. A., Morey, R. A., Smith, A. K., & Uddin, M. (2018). Genomic Approaches to Posttraumatic Stress Disorder: The Psychiatric Genomic Consortium Initiative. Biol Psychiatry, 83(10), 831–839. https://doi.org/10.1016/j.biopsych.2018.01.020
Nievergelt, Caroline M., Allison E. Ashley-Koch, Shareefa Dalvie, Michael A. Hauser, Rajendra A. Morey, Alicia K. Smith, and Monica Uddin. “Genomic Approaches to Posttraumatic Stress Disorder: The Psychiatric Genomic Consortium Initiative.Biol Psychiatry 83, no. 10 (May 15, 2018): 831–39. https://doi.org/10.1016/j.biopsych.2018.01.020.
Nievergelt CM, Ashley-Koch AE, Dalvie S, Hauser MA, Morey RA, Smith AK, et al. Genomic Approaches to Posttraumatic Stress Disorder: The Psychiatric Genomic Consortium Initiative. Biol Psychiatry. 2018 May 15;83(10):831–9.
Nievergelt, Caroline M., et al. “Genomic Approaches to Posttraumatic Stress Disorder: The Psychiatric Genomic Consortium Initiative.Biol Psychiatry, vol. 83, no. 10, May 2018, pp. 831–39. Pubmed, doi:10.1016/j.biopsych.2018.01.020.
Nievergelt CM, Ashley-Koch AE, Dalvie S, Hauser MA, Morey RA, Smith AK, Uddin M. Genomic Approaches to Posttraumatic Stress Disorder: The Psychiatric Genomic Consortium Initiative. Biol Psychiatry. 2018 May 15;83(10):831–839.
Journal cover image

Published In

Biol Psychiatry

DOI

EISSN

1873-2402

Publication Date

May 15, 2018

Volume

83

Issue

10

Start / End Page

831 / 839

Location

United States

Related Subject Headings

  • Stress Disorders, Post-Traumatic
  • Psychiatry
  • Humans
  • Genomics
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
  • Epigenomics
  • 52 Psychology
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences