Skip to main content
Journal cover image

Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis.

Publication ,  Journal Article
Bu, P; Chen, K-Y; Xiang, K; Johnson, C; Crown, SB; Rakhilin, N; Ai, Y; Wang, L; Xi, R; Astapova, I; Han, Y; Li, J; Barth, BB; Lu, M; Gao, Z ...
Published in: Cell Metab
June 5, 2018

Cancer metastasis accounts for the majority of cancer-related deaths and remains a clinical challenge. Metastatic cancer cells generally resemble cells of the primary cancer, but they may be influenced by the milieu of the organs they colonize. Here, we show that colorectal cancer cells undergo metabolic reprogramming after they metastasize and colonize the liver, a key metabolic organ. In particular, via GATA6, metastatic cells in the liver upregulate the enzyme aldolase B (ALDOB), which enhances fructose metabolism and provides fuel for major pathways of central carbon metabolism during tumor cell proliferation. Targeting ALDOB or reducing dietary fructose significantly reduces liver metastatic growth but has little effect on the primary tumor. Our findings suggest that metastatic cells can take advantage of reprogrammed metabolism in their new microenvironment, especially in a metabolically active organ such as the liver. Manipulation of involved pathways may affect the course of metastatic growth.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Cell Metab

DOI

EISSN

1932-7420

Publication Date

June 5, 2018

Volume

27

Issue

6

Start / End Page

1249 / 1262.e4

Location

United States

Related Subject Headings

  • Tumor Microenvironment
  • Neoplasm Metastasis
  • Mice, Inbred NOD
  • Mice, Inbred BALB C
  • Mice
  • Liver Neoplasms
  • Humans
  • HCT116 Cells
  • Fructose-Bisphosphate Aldolase
  • Fructose
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bu, P., Chen, K.-Y., Xiang, K., Johnson, C., Crown, S. B., Rakhilin, N., … Shen, X. (2018). Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis. Cell Metab, 27(6), 1249-1262.e4. https://doi.org/10.1016/j.cmet.2018.04.003
Bu, Pengcheng, Kai-Yuan Chen, Kun Xiang, Christelle Johnson, Scott B. Crown, Nikolai Rakhilin, Yiwei Ai, et al. “Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis.Cell Metab 27, no. 6 (June 5, 2018): 1249-1262.e4. https://doi.org/10.1016/j.cmet.2018.04.003.
Bu P, Chen K-Y, Xiang K, Johnson C, Crown SB, Rakhilin N, et al. Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis. Cell Metab. 2018 Jun 5;27(6):1249-1262.e4.
Bu, Pengcheng, et al. “Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis.Cell Metab, vol. 27, no. 6, June 2018, pp. 1249-1262.e4. Pubmed, doi:10.1016/j.cmet.2018.04.003.
Bu P, Chen K-Y, Xiang K, Johnson C, Crown SB, Rakhilin N, Ai Y, Wang L, Xi R, Astapova I, Han Y, Li J, Barth BB, Lu M, Gao Z, Mines R, Zhang L, Herman M, Hsu D, Zhang G-F, Shen X. Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis. Cell Metab. 2018 Jun 5;27(6):1249-1262.e4.
Journal cover image

Published In

Cell Metab

DOI

EISSN

1932-7420

Publication Date

June 5, 2018

Volume

27

Issue

6

Start / End Page

1249 / 1262.e4

Location

United States

Related Subject Headings

  • Tumor Microenvironment
  • Neoplasm Metastasis
  • Mice, Inbred NOD
  • Mice, Inbred BALB C
  • Mice
  • Liver Neoplasms
  • Humans
  • HCT116 Cells
  • Fructose-Bisphosphate Aldolase
  • Fructose