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Cumulative childhood risk is associated with a new measure of chronic inflammation in adulthood.

Publication ,  Journal Article
Rasmussen, LJH; Moffitt, TE; Eugen-Olsen, J; Belsky, DW; Danese, A; Harrington, H; Houts, RM; Poulton, R; Sugden, K; Williams, B; Caspi, A
Published in: Journal of child psychology and psychiatry, and allied disciplines
February 2019

Childhood risk factors are associated with elevated inflammatory biomarkers in adulthood, but it is unknown whether these risk factors are associated with increased adult levels of the chronic inflammation marker soluble urokinase plasminogen activator receptor (suPAR). We aimed to test the hypothesis that childhood exposure to risk factors for adult disease is associated with elevated suPAR in adulthood and to compare suPAR with the oft-reported inflammatory biomarker C-reactive protein (CRP).Prospective study of a population-representative 1972-1973 birth cohort; the Dunedin Multidisciplinary Health and Development Study observed participants to age 38 years. Main childhood predictors were poor health, socioeconomic disadvantage, adverse childhood experiences (ACEs), low IQ, and poor self-control. Main adult outcomes were adulthood inflammation measured as suPAR and high-sensitivity CRP (hsCRP).Participants with available plasma samples at age 38 were included (N = 837, 50.5% male). suPAR (mean 2.40 ng/ml; SD 0.91) was positively correlated with hsCRP (r 0.15, p < .001). After controlling for sex, body mass index (BMI), and smoking, children who experienced more ACEs, lower IQ, or had poorer self-control showed elevated adult suPAR. When the five childhood risks were aggregated into a Cumulative Childhood Risk index, and controlling for sex, BMI, and smoking, Cumulative Childhood Risk was associated with higher suPAR (b 0.10; SE 0.03; p = .002). Cumulative Childhood Risk predicted elevated suPAR, after controlling for hsCRP (b 0.18; SE 0.03; p < .001).Exposure to more childhood risk factors was associated with higher suPAR levels, independent of CRP. suPAR is a useful addition to studies connecting childhood risk to adult inflammatory burden.

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Published In

Journal of child psychology and psychiatry, and allied disciplines

DOI

EISSN

1469-7610

ISSN

0021-9630

Publication Date

February 2019

Volume

60

Issue

2

Start / End Page

199 / 208

Related Subject Headings

  • Self-Control
  • Risk Factors
  • Receptors, Urokinase Plasminogen Activator
  • Male
  • Intelligence
  • Inflammation
  • Humans
  • Health Status
  • Female
  • Developmental & Child Psychology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Rasmussen, L. J. H., Moffitt, T. E., Eugen-Olsen, J., Belsky, D. W., Danese, A., Harrington, H., … Caspi, A. (2019). Cumulative childhood risk is associated with a new measure of chronic inflammation in adulthood. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 60(2), 199–208. https://doi.org/10.1111/jcpp.12928
Rasmussen, Line Jee Hartmann, Terrie E. Moffitt, Jesper Eugen-Olsen, Daniel W. Belsky, Andrea Danese, HonaLee Harrington, Renate M. Houts, et al. “Cumulative childhood risk is associated with a new measure of chronic inflammation in adulthood.Journal of Child Psychology and Psychiatry, and Allied Disciplines 60, no. 2 (February 2019): 199–208. https://doi.org/10.1111/jcpp.12928.
Rasmussen LJH, Moffitt TE, Eugen-Olsen J, Belsky DW, Danese A, Harrington H, et al. Cumulative childhood risk is associated with a new measure of chronic inflammation in adulthood. Journal of child psychology and psychiatry, and allied disciplines. 2019 Feb;60(2):199–208.
Rasmussen, Line Jee Hartmann, et al. “Cumulative childhood risk is associated with a new measure of chronic inflammation in adulthood.Journal of Child Psychology and Psychiatry, and Allied Disciplines, vol. 60, no. 2, Feb. 2019, pp. 199–208. Epmc, doi:10.1111/jcpp.12928.
Rasmussen LJH, Moffitt TE, Eugen-Olsen J, Belsky DW, Danese A, Harrington H, Houts RM, Poulton R, Sugden K, Williams B, Caspi A. Cumulative childhood risk is associated with a new measure of chronic inflammation in adulthood. Journal of child psychology and psychiatry, and allied disciplines. 2019 Feb;60(2):199–208.
Journal cover image

Published In

Journal of child psychology and psychiatry, and allied disciplines

DOI

EISSN

1469-7610

ISSN

0021-9630

Publication Date

February 2019

Volume

60

Issue

2

Start / End Page

199 / 208

Related Subject Headings

  • Self-Control
  • Risk Factors
  • Receptors, Urokinase Plasminogen Activator
  • Male
  • Intelligence
  • Inflammation
  • Humans
  • Health Status
  • Female
  • Developmental & Child Psychology