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The impact of transplant rejection on cutaneous squamous cell carcinoma in renal transplant recipients.

Publication ,  Journal Article
Puza, CJ; Myers, SA; Cardones, AR; Beasley, GM; Mosca, PJ
Published in: Clin Exp Dermatol
April 2019

BACKGROUND: The incidence of cutaneous squamous cell carcinoma (cSCC) is markedly increased in renal transplant recipients compared with that of the nontransplant population. AIM: To investigate whether there is a relationship between transplant rejection and cSCC. METHODS: The Duke Enterprise Data Unified Content Explorer historical database was used to identify patients who had undergone a renal transplant at Duke University Hospital during a 20-year period. Data on patient demographics, transplant dates, first rejection episodes, first cSCC development, medication, laboratory results and survival were recorded. RESULTS: In total, 1684 patients were identified, of whom 126 (7.5%) experienced an episode of rejection and 46 (4.0%) developed a cSCC after transplant. The incidence of cSCC was significantly greater in the rejection group, with 8.7% of patients developing cSCC compared with 2.2% in the no-rejection group (P < 0.001). Median lag time to cSCC was shorter in the rejection group (2.5 years; age 0.4-9.0 years) than the no-rejection group (4.2 years; range 1.3-20.4 years) (P < 0.03). CONCLUSIONS: Transplant rejection is associated with both a higher incidence and an accelerated time course for development of cSCC following renal transplantation. Close dermatological surveillance should be considered following an episode of rejection in this patient population.

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Published In

Clin Exp Dermatol

DOI

EISSN

1365-2230

Publication Date

April 2019

Volume

44

Issue

3

Start / End Page

265 / 269

Location

England

Related Subject Headings

  • Skin Neoplasms
  • Population Surveillance
  • Middle Aged
  • Male
  • Kidney Transplantation
  • Incidence
  • Humans
  • Graft Rejection
  • Female
  • Dermatology & Venereal Diseases
 

Citation

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Puza, C. J., Myers, S. A., Cardones, A. R., Beasley, G. M., & Mosca, P. J. (2019). The impact of transplant rejection on cutaneous squamous cell carcinoma in renal transplant recipients. Clin Exp Dermatol, 44(3), 265–269. https://doi.org/10.1111/ced.13699
Puza, C. J., S. A. Myers, A. R. Cardones, G. M. Beasley, and P. J. Mosca. “The impact of transplant rejection on cutaneous squamous cell carcinoma in renal transplant recipients.Clin Exp Dermatol 44, no. 3 (April 2019): 265–69. https://doi.org/10.1111/ced.13699.
Puza CJ, Myers SA, Cardones AR, Beasley GM, Mosca PJ. The impact of transplant rejection on cutaneous squamous cell carcinoma in renal transplant recipients. Clin Exp Dermatol. 2019 Apr;44(3):265–9.
Puza, C. J., et al. “The impact of transplant rejection on cutaneous squamous cell carcinoma in renal transplant recipients.Clin Exp Dermatol, vol. 44, no. 3, Apr. 2019, pp. 265–69. Pubmed, doi:10.1111/ced.13699.
Puza CJ, Myers SA, Cardones AR, Beasley GM, Mosca PJ. The impact of transplant rejection on cutaneous squamous cell carcinoma in renal transplant recipients. Clin Exp Dermatol. 2019 Apr;44(3):265–269.

Published In

Clin Exp Dermatol

DOI

EISSN

1365-2230

Publication Date

April 2019

Volume

44

Issue

3

Start / End Page

265 / 269

Location

England

Related Subject Headings

  • Skin Neoplasms
  • Population Surveillance
  • Middle Aged
  • Male
  • Kidney Transplantation
  • Incidence
  • Humans
  • Graft Rejection
  • Female
  • Dermatology & Venereal Diseases