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Correlation Between Anti-gp41 Antibodies and Virus Infectivity Decay During Primary HIV-1 Infection.

Publication ,  Journal Article
Vaidya, NK; Ribeiro, RM; Liu, P; Haynes, BF; Tomaras, GD; Perelson, AS
Published in: Front Microbiol
2018

Recent experiments have suggested that the infectivity of simian immunodeficiency virus (SIV) and human immunodeficiency virus type-1 (HIV-1) in plasma decreases over time during primary infection. Because anti-gp41 antibodies are produced early during HIV-1 infection and form antibody-virion complexes, we studied if such early HIV-1 specific antibodies are correlated with the decay in HIV-1 infectivity. Using a viral dynamic model that allows viral infectivity to decay and frequent early viral load data obtained from 6 plasma donors we estimate that HIV-1 infectivity begins to decay after about 2 weeks of infection. The length of this delay is consistent with the time before antibody-virion complexes were detected in the plasma of these donors and is correlated (p = 0.023, r = 0.87) with the time for antibodies to be first detected in plasma. Importantly, we identify that the rate of infectivity decay is significantly correlated with the rate of increase in plasma anti-gp41 IgG concentration (p = 0.046, r = 0.82) and the increase in IgM+IgG anti-gp41 concentration (p = 8.37 × 10-4, r = 0.98). Furthermore, we found that the viral load decay after the peak did not have any significant correlation with the rate of anti-gp41 IgM or IgG increase. These results indicate that early anti-gp41 antibodies may cause viral infectivity decay, but may not contribute significantly to controlling post-peak viral load, likely due to insufficient quantity or affinity. Our findings may be helpful to devise strategies, including antibody-based vaccines, to control acute HIV-1 infection.

Duke Scholars

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Published In

Front Microbiol

DOI

ISSN

1664-302X

Publication Date

2018

Volume

9

Start / End Page

1326

Location

Switzerland

Related Subject Headings

  • 3207 Medical microbiology
  • 3107 Microbiology
  • 0605 Microbiology
  • 0503 Soil Sciences
  • 0502 Environmental Science and Management
 

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Chicago
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MLA
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Vaidya, N. K., Ribeiro, R. M., Liu, P., Haynes, B. F., Tomaras, G. D., & Perelson, A. S. (2018). Correlation Between Anti-gp41 Antibodies and Virus Infectivity Decay During Primary HIV-1 Infection. Front Microbiol, 9, 1326. https://doi.org/10.3389/fmicb.2018.01326
Vaidya, Naveen K., Ruy M. Ribeiro, Pinghuang Liu, Barton F. Haynes, Georgia D. Tomaras, and Alan S. Perelson. “Correlation Between Anti-gp41 Antibodies and Virus Infectivity Decay During Primary HIV-1 Infection.Front Microbiol 9 (2018): 1326. https://doi.org/10.3389/fmicb.2018.01326.
Vaidya NK, Ribeiro RM, Liu P, Haynes BF, Tomaras GD, Perelson AS. Correlation Between Anti-gp41 Antibodies and Virus Infectivity Decay During Primary HIV-1 Infection. Front Microbiol. 2018;9:1326.
Vaidya, Naveen K., et al. “Correlation Between Anti-gp41 Antibodies and Virus Infectivity Decay During Primary HIV-1 Infection.Front Microbiol, vol. 9, 2018, p. 1326. Pubmed, doi:10.3389/fmicb.2018.01326.
Vaidya NK, Ribeiro RM, Liu P, Haynes BF, Tomaras GD, Perelson AS. Correlation Between Anti-gp41 Antibodies and Virus Infectivity Decay During Primary HIV-1 Infection. Front Microbiol. 2018;9:1326.

Published In

Front Microbiol

DOI

ISSN

1664-302X

Publication Date

2018

Volume

9

Start / End Page

1326

Location

Switzerland

Related Subject Headings

  • 3207 Medical microbiology
  • 3107 Microbiology
  • 0605 Microbiology
  • 0503 Soil Sciences
  • 0502 Environmental Science and Management