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Effectiveness of high rate and delayed detection ICD programming by race: A MADIT-RIT substudy.

Publication ,  Journal Article
Jackson, LR; Thomas, KL; Polonsky, B; Zareba, W; Lahiri, M; Saba, S; McNitt, S; Schuger, C; Daubert, JP; Moss, AJ; Kutyifa, V
Published in: J Cardiovasc Electrophysiol
October 2018

INTRODUCTION: Data on inappropriate and appropriate ICD therapy, and efficacy of ICD programing strategies by race are limited. METHODS: In MADIT-RIT, we evaluated the risk of ICD therapy by race, and the efficacy of high rate cut-off ventricular tachycardia (VT) zone ≥200 beats per minute (bpm) (Arm B), or 60 seconds delay in VT zone 170-199 bpm (Arm C), compared to 2.5 seconds delay at 170 bpm (Arm A) among black and white patients. RESULTS: MADIT-RIT enrolled 272 (20%) black and 1119 (80%) white patients. The risk of inappropriate therapy was similar among blacks and whites, HR 1.25, 95% CI (0.82-1.93), P  =  0.30. High rate cut-off or delayed VT therapy was associated with significant reductions in inappropriate therapy among whites, Arm B versus Arm A, HR 0.15, 95% CI (0.08-0.29), P < 0.0001, Arm C versus Arm A, HR 0.19, 95% CI (0.11-0.33), P < 0.001, and black individuals Arm B versus Arm A, HR 0.24, 95% CI (0.01-0.56), P  =  0.0001, Arm C versus Arm A, HR 0.30, 95% CI (0.13-0.68), P  =  0.004, P interaction > 0.10). However, delayed VT therapy was associated with a trend toward greater reduction in appropriate therapy in black individuals, HR 0.08, 95% CI (0.03-0.27), P < 0.0001 relative to white individuals, HR 0.27, 95% CI (0.16-0.43), P < 0.0001, P interaction  =  0.077. CONCLUSION: In MADIT-RIT, high rate and delayed detection ICD programming provided similar benefit with reductions in both inappropriate therapy and unnecessary appropriate therapy among black and white individuals. CLINICALTRIALS. GOV IDENTIFIER: NCT00947310.

Duke Scholars

Published In

J Cardiovasc Electrophysiol

DOI

EISSN

1540-8167

Publication Date

October 2018

Volume

29

Issue

10

Start / End Page

1418 / 1424

Location

United States

Related Subject Headings

  • White People
  • Unnecessary Procedures
  • Treatment Outcome
  • Time Factors
  • Tachycardia, Ventricular
  • Risk Factors
  • Risk Assessment
  • Retrospective Studies
  • Randomized Controlled Trials as Topic
  • Prosthesis Failure
 

Citation

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Jackson, L. R., Thomas, K. L., Polonsky, B., Zareba, W., Lahiri, M., Saba, S., … Kutyifa, V. (2018). Effectiveness of high rate and delayed detection ICD programming by race: A MADIT-RIT substudy. J Cardiovasc Electrophysiol, 29(10), 1418–1424. https://doi.org/10.1111/jce.13693
Jackson, Larry R., Kevin L. Thomas, Bronislava Polonsky, Wojciech Zareba, Marc Lahiri, Samir Saba, Scott McNitt, et al. “Effectiveness of high rate and delayed detection ICD programming by race: A MADIT-RIT substudy.J Cardiovasc Electrophysiol 29, no. 10 (October 2018): 1418–24. https://doi.org/10.1111/jce.13693.
Jackson LR, Thomas KL, Polonsky B, Zareba W, Lahiri M, Saba S, et al. Effectiveness of high rate and delayed detection ICD programming by race: A MADIT-RIT substudy. J Cardiovasc Electrophysiol. 2018 Oct;29(10):1418–24.
Jackson, Larry R., et al. “Effectiveness of high rate and delayed detection ICD programming by race: A MADIT-RIT substudy.J Cardiovasc Electrophysiol, vol. 29, no. 10, Oct. 2018, pp. 1418–24. Pubmed, doi:10.1111/jce.13693.
Jackson LR, Thomas KL, Polonsky B, Zareba W, Lahiri M, Saba S, McNitt S, Schuger C, Daubert JP, Moss AJ, Kutyifa V. Effectiveness of high rate and delayed detection ICD programming by race: A MADIT-RIT substudy. J Cardiovasc Electrophysiol. 2018 Oct;29(10):1418–1424.
Journal cover image

Published In

J Cardiovasc Electrophysiol

DOI

EISSN

1540-8167

Publication Date

October 2018

Volume

29

Issue

10

Start / End Page

1418 / 1424

Location

United States

Related Subject Headings

  • White People
  • Unnecessary Procedures
  • Treatment Outcome
  • Time Factors
  • Tachycardia, Ventricular
  • Risk Factors
  • Risk Assessment
  • Retrospective Studies
  • Randomized Controlled Trials as Topic
  • Prosthesis Failure