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A Specialized Neural Circuit Gates Social Vocalizations in the Mouse.

Publication ,  Journal Article
Tschida, K; Michael, V; Takatoh, J; Han, B-X; Zhao, S; Sakurai, K; Mooney, R; Wang, F
Published in: Neuron
August 7, 2019

Vocalizations are fundamental to mammalian communication, but the underlying neural circuits await detailed characterization. Here, we used an intersectional genetic method to label and manipulate neurons in the midbrain periaqueductal gray (PAG) that are transiently active in male mice when they produce ultrasonic courtship vocalizations (USVs). Genetic silencing of PAG-USV neurons rendered males unable to produce USVs and impaired their ability to attract females. Conversely, activating PAG-USV neurons selectively triggered USV production, even in the absence of any female cues. Optogenetic stimulation combined with axonal tracing indicates that PAG-USV neurons gate downstream vocal-patterning circuits. Indeed, activating PAG neurons that innervate the nucleus retroambiguus, but not those innervating the parabrachial nucleus, elicited USVs in both male and female mice. These experiments establish that a dedicated population of PAG neurons gives rise to a descending circuit necessary and sufficient for USV production while also demonstrating the communicative salience of male USVs. VIDEO ABSTRACT.

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Published In

Neuron

DOI

EISSN

1097-4199

Publication Date

August 7, 2019

Volume

103

Issue

3

Start / End Page

459 / 472.e4

Location

United States

Related Subject Headings

  • Vocalization, Animal
  • Respiratory Center
  • Periaqueductal Gray
  • Optogenetics
  • Neurotransmitter Agents
  • Neurons
  • Neurology & Neurosurgery
  • Nerve Net
  • Mice
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Tschida, K., Michael, V., Takatoh, J., Han, B.-X., Zhao, S., Sakurai, K., … Wang, F. (2019). A Specialized Neural Circuit Gates Social Vocalizations in the Mouse. Neuron, 103(3), 459-472.e4. https://doi.org/10.1016/j.neuron.2019.05.025
Tschida, Katherine, Valerie Michael, Jun Takatoh, Bao-Xia Han, Shengli Zhao, Katsuyasu Sakurai, Richard Mooney, and Fan Wang. “A Specialized Neural Circuit Gates Social Vocalizations in the Mouse.Neuron 103, no. 3 (August 7, 2019): 459-472.e4. https://doi.org/10.1016/j.neuron.2019.05.025.
Tschida K, Michael V, Takatoh J, Han B-X, Zhao S, Sakurai K, et al. A Specialized Neural Circuit Gates Social Vocalizations in the Mouse. Neuron. 2019 Aug 7;103(3):459-472.e4.
Tschida, Katherine, et al. “A Specialized Neural Circuit Gates Social Vocalizations in the Mouse.Neuron, vol. 103, no. 3, Aug. 2019, pp. 459-472.e4. Pubmed, doi:10.1016/j.neuron.2019.05.025.
Tschida K, Michael V, Takatoh J, Han B-X, Zhao S, Sakurai K, Mooney R, Wang F. A Specialized Neural Circuit Gates Social Vocalizations in the Mouse. Neuron. 2019 Aug 7;103(3):459-472.e4.
Journal cover image

Published In

Neuron

DOI

EISSN

1097-4199

Publication Date

August 7, 2019

Volume

103

Issue

3

Start / End Page

459 / 472.e4

Location

United States

Related Subject Headings

  • Vocalization, Animal
  • Respiratory Center
  • Periaqueductal Gray
  • Optogenetics
  • Neurotransmitter Agents
  • Neurons
  • Neurology & Neurosurgery
  • Nerve Net
  • Mice
  • Male