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Perivascular dendritic cells elicit anaphylaxis by relaying allergens to mast cells via microvesicles.

Publication ,  Journal Article
Choi, HW; Suwanpradid, J; Kim, IH; Staats, HF; Haniffa, M; MacLeod, AS; Abraham, SN
Published in: Science
November 9, 2018

Anaphylactic reactions are triggered when allergens enter the blood circulation and activate immunoglobulin E (IgE)-sensitized mast cells (MCs), causing systemic discharge of prestored proinflammatory mediators. As MCs are extravascular, how they perceive circulating allergens remains a conundrum. Here, we describe the existence of a CD301b+ perivascular dendritic cell (DC) subset that continuously samples blood and relays antigens to neighboring MCs, which vigorously degranulate and trigger anaphylaxis. DC antigen transfer involves the active discharge of surface-associated antigens on 0.5- to 1.0-micrometer microvesicles (MVs) generated by vacuolar protein sorting 4 (VPS4). Antigen sharing by DCs is not limited to MCs, as neighboring DCs also acquire antigen-bearing MVs. This capacity of DCs to distribute antigen-bearing MVs to various immune cells in the perivascular space potentiates inflammatory and immune responses to blood-borne antigens.

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Published In

Science

DOI

EISSN

1095-9203

Publication Date

November 9, 2018

Volume

362

Issue

6415

Location

United States

Related Subject Headings

  • Skin
  • Primary Cell Culture
  • Mice, Mutant Strains
  • Mice, Inbred C57BL
  • Mice
  • Mast Cells
  • Male
  • Lectins, C-Type
  • Humans
  • General Science & Technology
 

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Choi, H. W., Suwanpradid, J., Kim, I. H., Staats, H. F., Haniffa, M., MacLeod, A. S., & Abraham, S. N. (2018). Perivascular dendritic cells elicit anaphylaxis by relaying allergens to mast cells via microvesicles. Science, 362(6415). https://doi.org/10.1126/science.aao0666
Choi, Hae Woong, Jutamas Suwanpradid, Il Hwan Kim, Herman F. Staats, Muzlifah Haniffa, Amanda S. MacLeod, and Soman N. Abraham. “Perivascular dendritic cells elicit anaphylaxis by relaying allergens to mast cells via microvesicles.Science 362, no. 6415 (November 9, 2018). https://doi.org/10.1126/science.aao0666.
Choi HW, Suwanpradid J, Kim IH, Staats HF, Haniffa M, MacLeod AS, et al. Perivascular dendritic cells elicit anaphylaxis by relaying allergens to mast cells via microvesicles. Science. 2018 Nov 9;362(6415).
Choi, Hae Woong, et al. “Perivascular dendritic cells elicit anaphylaxis by relaying allergens to mast cells via microvesicles.Science, vol. 362, no. 6415, Nov. 2018. Pubmed, doi:10.1126/science.aao0666.
Choi HW, Suwanpradid J, Kim IH, Staats HF, Haniffa M, MacLeod AS, Abraham SN. Perivascular dendritic cells elicit anaphylaxis by relaying allergens to mast cells via microvesicles. Science. 2018 Nov 9;362(6415).
Journal cover image

Published In

Science

DOI

EISSN

1095-9203

Publication Date

November 9, 2018

Volume

362

Issue

6415

Location

United States

Related Subject Headings

  • Skin
  • Primary Cell Culture
  • Mice, Mutant Strains
  • Mice, Inbred C57BL
  • Mice
  • Mast Cells
  • Male
  • Lectins, C-Type
  • Humans
  • General Science & Technology