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The role of tumor phenotype in the surgical treatment of early-stage breast cancer.

Publication ,  Conference
Rooney, MM; Thomas, SM; Taskindoust, M; Greenup, RA; Rosenberger, LH; Hwang, ES; Plichta, JK
Published in: Am J Surg
January 2023

BACKGROUND: We investigated whether tumor phenotype influences surgical decision-making, and how that may impact overall survival (OS) for early-stage breast cancer. METHODS: Women aged 18-69 with cT0-2/cN0/cM0 breast cancer in the National Cancer Database (2010-2017) were included. A generalized logistic model was used to identify factors associated with surgery type. A Kaplan-Meier curve was used to visualize unadjusted OS, and the log-rank test was used to test for differences in OS between surgery types. RESULTS: Of 597,149 patients, 58% underwent lumpectomy with radiation (BCT), 25% unilateral mastectomy (UM), and 17% bilateral mastectomy (BM). After adjustment, HER2+ and triple-negative (TN) tumors were less likely to undergo UM than BCT, versus hormone receptor-positive tumors (OR = 0.881, 95% CI = 0.860-0.903; OR = 0.485, 95% CI = 0.470-0.501). UM and BM had worse 5-year OS versus BCT (UM: 0.926, vs BM: 0.952, vs BCT: 0.960). CONCLUSIONS: BCT is increasingly used to treat HER2+ and TN tumors. More extensive surgery is not associated with better survival outcomes, regardless of tumor phenotype.

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Published In

Am J Surg

DOI

EISSN

1879-1883

Publication Date

January 2023

Volume

225

Issue

1

Start / End Page

84 / 92

Location

United States

Related Subject Headings

  • Surgery
  • Phenotype
  • Neoplasms
  • Mastectomy, Segmental
  • Mastectomy
  • Humans
  • Female
  • 3203 Dentistry
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Rooney, M. M., Thomas, S. M., Taskindoust, M., Greenup, R. A., Rosenberger, L. H., Hwang, E. S., & Plichta, J. K. (2023). The role of tumor phenotype in the surgical treatment of early-stage breast cancer. In Am J Surg (Vol. 225, pp. 84–92). United States. https://doi.org/10.1016/j.amjsurg.2022.09.029
Rooney, Marguerite M., Samantha M. Thomas, Mahsa Taskindoust, Rachel A. Greenup, Laura H. Rosenberger, E Shelley Hwang, and Jennifer K. Plichta. “The role of tumor phenotype in the surgical treatment of early-stage breast cancer.” In Am J Surg, 225:84–92, 2023. https://doi.org/10.1016/j.amjsurg.2022.09.029.
Rooney MM, Thomas SM, Taskindoust M, Greenup RA, Rosenberger LH, Hwang ES, et al. The role of tumor phenotype in the surgical treatment of early-stage breast cancer. In: Am J Surg. 2023. p. 84–92.
Rooney, Marguerite M., et al. “The role of tumor phenotype in the surgical treatment of early-stage breast cancer.Am J Surg, vol. 225, no. 1, 2023, pp. 84–92. Pubmed, doi:10.1016/j.amjsurg.2022.09.029.
Rooney MM, Thomas SM, Taskindoust M, Greenup RA, Rosenberger LH, Hwang ES, Plichta JK. The role of tumor phenotype in the surgical treatment of early-stage breast cancer. Am J Surg. 2023. p. 84–92.
Journal cover image

Published In

Am J Surg

DOI

EISSN

1879-1883

Publication Date

January 2023

Volume

225

Issue

1

Start / End Page

84 / 92

Location

United States

Related Subject Headings

  • Surgery
  • Phenotype
  • Neoplasms
  • Mastectomy, Segmental
  • Mastectomy
  • Humans
  • Female
  • 3203 Dentistry
  • 3202 Clinical sciences
  • 1103 Clinical Sciences