
Functional CD3+CD8+PD1- T Cell Accumulation and PD-L1 Expression Increases During Tumor Invasion in DCIS of the Breast.
BACKGROUND: The changes in T cell subsets and programmed death ligand 1 (PD-L1) expression during the transition from ductal carcinoma in situ (DCIS) to early invasive breast cancer had not been well studied. PATIENTS AND METHODS: A total of 85 DCIS patients were classified into 49 DCIS (clinical stage: Tis, noninvasive) and 36 with a minimally infiltrating lesion (MIL; < 5 mm; clinical stage: T1a). We explored the quantitative alterations of T-cell markers and PD-L1 in these groups using the Opal multi-immunohistochemistry technique. RESULTS: We observed increased infiltration of CD3-positive (CD3+)CD8+ programmed death 1 (PD1)-negative T cells and higher PD-L1 expression in DCIS with MIL. Elevated PD1 expression correlated with PD-L1 expression in MIL and DCIS. CONCLUSION: We conclude that during the transition from DCIS to an invasive lesion, the host cytolytic T cells begin interacting with the tumor and destroy the tumor tissue, leading to an adaptive upregulation of PD-L1 and tumor protection against immune destruction.
Duke Scholars
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Tumor Microenvironment
- Retrospective Studies
- Receptor, erbB-2
- Receptor, ErbB-2
- Programmed Cell Death 1 Receptor
- Prognosis
- Oncology & Carcinogenesis
- Neoplasm Invasiveness
- Middle Aged
- Lymphocytes, Tumor-Infiltrating
Citation

Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Tumor Microenvironment
- Retrospective Studies
- Receptor, erbB-2
- Receptor, ErbB-2
- Programmed Cell Death 1 Receptor
- Prognosis
- Oncology & Carcinogenesis
- Neoplasm Invasiveness
- Middle Aged
- Lymphocytes, Tumor-Infiltrating