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Engineered skeletal muscles for disease modeling and drug discovery.

Publication ,  Journal Article
Wang, J; Khodabukus, A; Rao, L; Vandusen, K; Abutaleb, N; Bursac, N
Published in: Biomaterials
November 2019

Skeletal muscle is the largest organ of human body with several important roles in everyday movement and metabolic homeostasis. The limited ability of small animal models of muscle disease to accurately predict drug efficacy and toxicity in humans has prompted the development in vitro models of human skeletal muscle that fatefully recapitulate cell and tissue level functions and drug responses. We first review methods for development of three-dimensional engineered muscle tissues and organ-on-a-chip microphysiological systems and discuss their potential utility in drug discovery research and development of new regenerative therapies. Furthermore, we describe strategies to increase the functional maturation of engineered muscle, and motivate the importance of incorporating multiple tissue types on the same chip to model organ cross-talk and generate more predictive drug development platforms. Finally, we review the ability of available in vitro systems to model diseases such as type II diabetes, Duchenne muscular dystrophy, Pompe disease, and dysferlinopathy.

Duke Scholars

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Published In

Biomaterials

DOI

EISSN

1878-5905

ISSN

0142-9612

Publication Date

November 2019

Volume

221

Start / End Page

119416

Related Subject Headings

  • Tissue Engineering
  • Muscular Dystrophies
  • Muscle, Skeletal
  • Induced Pluripotent Stem Cells
  • Humans
  • Drug Discovery
  • Biomedical Engineering
 

Citation

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Wang, J., Khodabukus, A., Rao, L., Vandusen, K., Abutaleb, N., & Bursac, N. (2019). Engineered skeletal muscles for disease modeling and drug discovery. Biomaterials, 221, 119416. https://doi.org/10.1016/j.biomaterials.2019.119416
Wang, Jason, Alastair Khodabukus, Lingjun Rao, Keith Vandusen, Nadia Abutaleb, and Nenad Bursac. “Engineered skeletal muscles for disease modeling and drug discovery.Biomaterials 221 (November 2019): 119416. https://doi.org/10.1016/j.biomaterials.2019.119416.
Wang J, Khodabukus A, Rao L, Vandusen K, Abutaleb N, Bursac N. Engineered skeletal muscles for disease modeling and drug discovery. Biomaterials. 2019 Nov;221:119416.
Wang, Jason, et al. “Engineered skeletal muscles for disease modeling and drug discovery.Biomaterials, vol. 221, Nov. 2019, p. 119416. Epmc, doi:10.1016/j.biomaterials.2019.119416.
Wang J, Khodabukus A, Rao L, Vandusen K, Abutaleb N, Bursac N. Engineered skeletal muscles for disease modeling and drug discovery. Biomaterials. 2019 Nov;221:119416.
Journal cover image

Published In

Biomaterials

DOI

EISSN

1878-5905

ISSN

0142-9612

Publication Date

November 2019

Volume

221

Start / End Page

119416

Related Subject Headings

  • Tissue Engineering
  • Muscular Dystrophies
  • Muscle, Skeletal
  • Induced Pluripotent Stem Cells
  • Humans
  • Drug Discovery
  • Biomedical Engineering