Clinical outcome measures following plasma exchange for MG exacerbation.
Publication
, Journal Article
Raja, SM; Howard, JF; Juel, VC; Massey, JM; Chopra, M; Guptill, JT
Published in: Ann Clin Transl Neurol
October 2019
Our objective is to report longitudinal results of the MG-ADL, MG-Composite, MG-MMT, and MG-QoL15 in an open-label trial of therapeutic plasma exchange in myasthenia gravis. Ten MG patients experiencing exacerbation had assessments prior to, immediately following, and at selected time points post-TPE. Changes from baseline to 2 weeks post-TPE were: MG-ADL median -5.0, P < 0.0033, MG-QoL15 median -13.0, P < 0.001, MG-MMT median -10.0, P < 0.0001, and MG-Composite median -10.0, P < 0.005. TPE produced a rapid, clinically significant change in all instruments, indicating these outcome measures are robust endpoints for clinical trials of rapidly efficacious MG therapies.
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Published In
Ann Clin Transl Neurol
DOI
EISSN
2328-9503
Publication Date
October 2019
Volume
6
Issue
10
Start / End Page
2114 / 2119
Location
United States
Related Subject Headings
- Young Adult
- Symptom Flare Up
- Plasma Exchange
- Outcome Assessment, Health Care
- Myasthenia Gravis
- Middle Aged
- Male
- Longitudinal Studies
- Humans
- Female
Citation
APA
Chicago
ICMJE
MLA
NLM
Raja, S. M., Howard, J. F., Juel, V. C., Massey, J. M., Chopra, M., & Guptill, J. T. (2019). Clinical outcome measures following plasma exchange for MG exacerbation. Ann Clin Transl Neurol, 6(10), 2114–2119. https://doi.org/10.1002/acn3.50901
Raja, Shruti M., James F. Howard, Vern C. Juel, Janice M. Massey, Manisha Chopra, and Jeffrey T. Guptill. “Clinical outcome measures following plasma exchange for MG exacerbation.” Ann Clin Transl Neurol 6, no. 10 (October 2019): 2114–19. https://doi.org/10.1002/acn3.50901.
Raja SM, Howard JF, Juel VC, Massey JM, Chopra M, Guptill JT. Clinical outcome measures following plasma exchange for MG exacerbation. Ann Clin Transl Neurol. 2019 Oct;6(10):2114–9.
Raja, Shruti M., et al. “Clinical outcome measures following plasma exchange for MG exacerbation.” Ann Clin Transl Neurol, vol. 6, no. 10, Oct. 2019, pp. 2114–19. Pubmed, doi:10.1002/acn3.50901.
Raja SM, Howard JF, Juel VC, Massey JM, Chopra M, Guptill JT. Clinical outcome measures following plasma exchange for MG exacerbation. Ann Clin Transl Neurol. 2019 Oct;6(10):2114–2119.
Published In
Ann Clin Transl Neurol
DOI
EISSN
2328-9503
Publication Date
October 2019
Volume
6
Issue
10
Start / End Page
2114 / 2119
Location
United States
Related Subject Headings
- Young Adult
- Symptom Flare Up
- Plasma Exchange
- Outcome Assessment, Health Care
- Myasthenia Gravis
- Middle Aged
- Male
- Longitudinal Studies
- Humans
- Female