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Appearance of pediatric choroidal neovascular membranes on optical coherence tomography angiography.

Publication ,  Journal Article
Ong, SS; Hsu, ST; Grewal, D; Arevalo, JF; El-Dairi, MA; Toth, CA; Vajzovic, L
Published in: Graefes Arch Clin Exp Ophthalmol
January 2020

PURPOSE: Compared with fluorescein angiography (FA), the gold standard for diagnosing choroidal neovascularization (CNV) activity, optical coherence tomography angiography (OCTA) is non-invasive without risks associated with fluorescein dye use, and may be especially advantageous in the diagnosis and monitoring of children with CNV. METHODS: Eight eyes from eight patients aged 12 months to 18 years were imaged with the investigational Spectralis OCTA (version 6.9, Heidelberg Engineering, Heidelberg, Germany) and the RTVue XR Avanti (Optovue Inc., Fremont, CA, USA). Two patients were imaged during examination under anesthesia while six patients were imaged in the clinic. Demographic information, ocular characteristics, treatment history, and imaging studies (color photos, fluorescein angiography, OCT) were collected and reviewed. RESULTS: Three eyes had active CNV while five had quiescent CNV at the time of imaging. CNV was idiopathic or secondary to trauma, retinal vascular dysgenesis versus retinopathy of prematurity, pigmentary retinopathy, Best vitelliform macular dystrophy, panuveitis, morning glory disc anomaly, and optic disc drusen. OCTA of two active CNV demonstrated presence of a main trunk with multiple fine capillaries, vessel loops, and anastomoses. OCTA was repeated after treatment for two CNV and demonstrated a decrease in size with loss of fine capillaries, vessel loops, and anastomoses. For the third active CNV, OCTA verified flow in the CNV complex despite the uncertainty of FA hyperfluorescence in the setting of grossly abnormal retinal vasculature. The five quiescent CNV all lacked fine capillaries, vessel loops, and anastomoses on OCTA. CONCLUSION: OCTA demonstrates morphological differences between active and quiescent pediatric CNV.

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Published In

Graefes Arch Clin Exp Ophthalmol

DOI

EISSN

1435-702X

Publication Date

January 2020

Volume

258

Issue

1

Start / End Page

89 / 98

Location

Germany

Related Subject Headings

  • Tomography, Optical Coherence
  • Retinal Vessels
  • Ophthalmology & Optometry
  • Male
  • Infant
  • Humans
  • Fundus Oculi
  • Fluorescein Angiography
  • Female
  • Choroidal Neovascularization
 

Citation

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Ong, S. S., Hsu, S. T., Grewal, D., Arevalo, J. F., El-Dairi, M. A., Toth, C. A., & Vajzovic, L. (2020). Appearance of pediatric choroidal neovascular membranes on optical coherence tomography angiography. Graefes Arch Clin Exp Ophthalmol, 258(1), 89–98. https://doi.org/10.1007/s00417-019-04535-4
Ong, Sally S., S Tammy Hsu, Dilraj Grewal, J Fernando Arevalo, Mays A. El-Dairi, Cynthia A. Toth, and Lejla Vajzovic. “Appearance of pediatric choroidal neovascular membranes on optical coherence tomography angiography.Graefes Arch Clin Exp Ophthalmol 258, no. 1 (January 2020): 89–98. https://doi.org/10.1007/s00417-019-04535-4.
Ong SS, Hsu ST, Grewal D, Arevalo JF, El-Dairi MA, Toth CA, et al. Appearance of pediatric choroidal neovascular membranes on optical coherence tomography angiography. Graefes Arch Clin Exp Ophthalmol. 2020 Jan;258(1):89–98.
Ong, Sally S., et al. “Appearance of pediatric choroidal neovascular membranes on optical coherence tomography angiography.Graefes Arch Clin Exp Ophthalmol, vol. 258, no. 1, Jan. 2020, pp. 89–98. Pubmed, doi:10.1007/s00417-019-04535-4.
Ong SS, Hsu ST, Grewal D, Arevalo JF, El-Dairi MA, Toth CA, Vajzovic L. Appearance of pediatric choroidal neovascular membranes on optical coherence tomography angiography. Graefes Arch Clin Exp Ophthalmol. 2020 Jan;258(1):89–98.
Journal cover image

Published In

Graefes Arch Clin Exp Ophthalmol

DOI

EISSN

1435-702X

Publication Date

January 2020

Volume

258

Issue

1

Start / End Page

89 / 98

Location

Germany

Related Subject Headings

  • Tomography, Optical Coherence
  • Retinal Vessels
  • Ophthalmology & Optometry
  • Male
  • Infant
  • Humans
  • Fundus Oculi
  • Fluorescein Angiography
  • Female
  • Choroidal Neovascularization