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Association Between Maternal Obesity and Group B Streptococcus Colonization in a National U.S. Cohort.

Publication ,  Conference
Venkatesh, KK; Vladutiu, CJ; Strauss, RA; Thorp, JM; Stringer, JSA; Stamilio, DM; Hughes, BL; Dotters-Katz, S
Published in: J Womens Health (Larchmt)
December 2020

Objective: To investigate the association between maternal obesity as measured by prepregnancy body mass index (BMI) and group B streptococcus (GBS) colonization. Methods: We conducted a secondary analysis from the Consortium on Safe Labor Study (CSL) in the United States cohort study (2002-2008). Pregnant women with deliveries at ≥37 weeks of gestation who attempted labor were included (115,070 assessed deliveries). The association between maternal prepregnancy BMI, categorized as normal weight or below (<25 kg/m2), overweight (25 to <30 kg/m2), class I obesity (30 to <35 kg/m2), class II obesity (35 to <40 kg/m2), and class III obesity (≥40 kg/m2), and GBS colonization was modeled using logistic regression with generalized estimating equations. Models adjusted for maternal age, parity, race, pregestational diabetes, insurance status, study site/region, and year of delivery. Results: The overall prevalence of GBS colonization was 20.5% (23,625/115,070), which increased with rising maternal BMI, normal weight 19.3% (13,543/70,098), overweight 20.8% (5,353/25,733), class I obesity 23.0% (2,596/11,275), class II obesity 26.1% (1,270/4,850), and class III obesity 27.7% (863/3,114). In multivariable analysis, increasing maternal obesity severity was associated with higher odds of GBS colonization, namely overweight (adjusted odds ratio [AOR]: 1.09, 95% confidence interval [CI]: 1.05-1.13), class I obesity (AOR: 1.20, 95% CI: 1.15-1.26), class II obesity (AOR: 1.42, 95% CI: 1.33-1.51), and class III obesity (AOR: 1.50; 95% CI: 1.38-1.62) compared with normal weight. In secondary analyses, these associations persisted when stratified by maternal race. Conclusions: In a national U.S. sample, increasing maternal obesity severity as assessed by prepregnancy BMI was associated with a higher likelihood of maternal GBS colonization during pregnancy.

Duke Scholars

Published In

J Womens Health (Larchmt)

DOI

EISSN

1931-843X

Publication Date

December 2020

Volume

29

Issue

12

Start / End Page

1507 / 1512

Location

United States

Related Subject Headings

  • United States
  • Streptococcus
  • Public Health
  • Premature Birth
  • Pregnancy
  • Obesity, Maternal
  • Infant, Newborn
  • Humans
  • Female
  • Cohort Studies
 

Citation

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MLA
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Venkatesh, K. K., Vladutiu, C. J., Strauss, R. A., Thorp, J. M., Stringer, J. S. A., Stamilio, D. M., … Dotters-Katz, S. (2020). Association Between Maternal Obesity and Group B Streptococcus Colonization in a National U.S. Cohort. In J Womens Health (Larchmt) (Vol. 29, pp. 1507–1512). United States. https://doi.org/10.1089/jwh.2019.8139
Venkatesh, Kartik K., Catherine J. Vladutiu, Robert A. Strauss, John M. Thorp, Jeffrey S. A. Stringer, David M. Stamilio, Brenna L. Hughes, and Sarah Dotters-Katz. “Association Between Maternal Obesity and Group B Streptococcus Colonization in a National U.S. Cohort.” In J Womens Health (Larchmt), 29:1507–12, 2020. https://doi.org/10.1089/jwh.2019.8139.
Venkatesh KK, Vladutiu CJ, Strauss RA, Thorp JM, Stringer JSA, Stamilio DM, et al. Association Between Maternal Obesity and Group B Streptococcus Colonization in a National U.S. Cohort. In: J Womens Health (Larchmt). 2020. p. 1507–12.
Venkatesh, Kartik K., et al. “Association Between Maternal Obesity and Group B Streptococcus Colonization in a National U.S. Cohort.J Womens Health (Larchmt), vol. 29, no. 12, 2020, pp. 1507–12. Pubmed, doi:10.1089/jwh.2019.8139.
Venkatesh KK, Vladutiu CJ, Strauss RA, Thorp JM, Stringer JSA, Stamilio DM, Hughes BL, Dotters-Katz S. Association Between Maternal Obesity and Group B Streptococcus Colonization in a National U.S. Cohort. J Womens Health (Larchmt). 2020. p. 1507–1512.
Journal cover image

Published In

J Womens Health (Larchmt)

DOI

EISSN

1931-843X

Publication Date

December 2020

Volume

29

Issue

12

Start / End Page

1507 / 1512

Location

United States

Related Subject Headings

  • United States
  • Streptococcus
  • Public Health
  • Premature Birth
  • Pregnancy
  • Obesity, Maternal
  • Infant, Newborn
  • Humans
  • Female
  • Cohort Studies