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Regional adiposity and heart failure with preserved ejection fraction.

Publication ,  Journal Article
Rao, VN; Fudim, M; Mentz, RJ; Michos, ED; Felker, GM
Published in: Eur J Heart Fail
September 2020

The role of obesity in the pathogenesis of heart failure (HF), and in particular HF with preserved ejection fraction (HFpEF), has drawn significant attention in recent years. The prevalence of both obesity and HFpEF has increased worldwide over the past decades and when present concomitantly suggests an obese-HFpEF phenotype. Anthropometrics, including body mass index, waist circumference, and waist-to-hip ratio, are associated with incident HFpEF. However, the cardiovascular effects of obesity may actually be driven by the distribution of fat, which can accumulate in the epicardial, visceral, and subcutaneous compartments. Regional fat can be quantified using non-invasive imaging techniques, including computed tomography, magnetic resonance imaging, and dual-energy X-ray absorptiometry. Regional variations in fat accumulation are associated with different HFpEF risk profiles, whereby higher epicardial and visceral fat have a much stronger association with HFpEF risk compared with elevated subcutaneous fat. Thus, regional adiposity may serve a pivotal role in the pathophysiology of HFpEF contributing to decreased cardiopulmonary fitness, impaired left ventricular compliance, upregulation of local and systemic inflammation, promotion of neurohormonal dysregulation, and increased intra-abdominal pressure and vascular congestion. Strategies to reduce total and regional adiposity have shown promise, including intensive exercise, dieting, and bariatric surgery programmes, but few studies have focused on HFpEF-related outcomes among obese. Further understanding the role these variable fat depots play in the progression of HFpEF and HFpEF-related hospitalizations may provide therapeutic targets in treating the obese-HFpEF phenotype.

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Published In

Eur J Heart Fail

DOI

EISSN

1879-0844

Publication Date

September 2020

Volume

22

Issue

9

Start / End Page

1540 / 1550

Location

England

Related Subject Headings

  • Stroke Volume
  • Obesity
  • Humans
  • Heart Failure
  • Cardiovascular System & Hematology
  • Body Mass Index
  • Adiposity
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

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Rao, V. N., Fudim, M., Mentz, R. J., Michos, E. D., & Felker, G. M. (2020). Regional adiposity and heart failure with preserved ejection fraction. Eur J Heart Fail, 22(9), 1540–1550. https://doi.org/10.1002/ejhf.1956
Rao, Vishal N., Marat Fudim, Robert J. Mentz, Erin D. Michos, and G Michael Felker. “Regional adiposity and heart failure with preserved ejection fraction.Eur J Heart Fail 22, no. 9 (September 2020): 1540–50. https://doi.org/10.1002/ejhf.1956.
Rao VN, Fudim M, Mentz RJ, Michos ED, Felker GM. Regional adiposity and heart failure with preserved ejection fraction. Eur J Heart Fail. 2020 Sep;22(9):1540–50.
Rao, Vishal N., et al. “Regional adiposity and heart failure with preserved ejection fraction.Eur J Heart Fail, vol. 22, no. 9, Sept. 2020, pp. 1540–50. Pubmed, doi:10.1002/ejhf.1956.
Rao VN, Fudim M, Mentz RJ, Michos ED, Felker GM. Regional adiposity and heart failure with preserved ejection fraction. Eur J Heart Fail. 2020 Sep;22(9):1540–1550.

Published In

Eur J Heart Fail

DOI

EISSN

1879-0844

Publication Date

September 2020

Volume

22

Issue

9

Start / End Page

1540 / 1550

Location

England

Related Subject Headings

  • Stroke Volume
  • Obesity
  • Humans
  • Heart Failure
  • Cardiovascular System & Hematology
  • Body Mass Index
  • Adiposity
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology