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Coronavirus Disease 2019 and Hypertension: The Role of Angiotensin-Converting Enzyme 2 and the Renin-Angiotensin System.

Publication ,  Journal Article
Edmonston, DL; South, AM; Sparks, MA; Cohen, JB
Published in: Adv Chronic Kidney Dis
September 2020

Hypertension emerged from early reports as a potential risk factor for worse outcomes for persons with coronavirus disease 2019 (COVID-19). Among the putative links between hypertension and COVID-19 is a key counter-regulatory component of the renin-angiotensin system (RAS): angiotensin-converting enzyme 2 (ACE2). ACE2 facilitates entry of severe acute respiratory syndrome coronavirus 2, the virus responsible for COVID-19, into host cells. Because RAS inhibitors have been suggested to increase ACE2 expression, health-care providers and patients have grappled with the decision of whether to discontinue these medications during the COVID-19 pandemic. However, experimental models of analogous viral pneumonias suggest RAS inhibitors may exert protective effects against acute lung injury. We review how RAS and ACE2 biology may affect outcomes in COVID-19 through pulmonary and other systemic effects. In addition, we briefly detail the data for and against continuation of RAS inhibitors in persons with COVID-19 and summarize the current consensus recommendations from select specialty organizations.

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Published In

Adv Chronic Kidney Dis

DOI

EISSN

1548-5609

Publication Date

September 2020

Volume

27

Issue

5

Start / End Page

404 / 411

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Up-Regulation
  • SARS-CoV-2
  • Risk Factors
  • Renin-Angiotensin System
  • Receptors, Coronavirus
  • Protective Factors
  • Peptide Fragments
  • MAP Kinase Signaling System
  • Lung
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Edmonston, D. L., South, A. M., Sparks, M. A., & Cohen, J. B. (2020). Coronavirus Disease 2019 and Hypertension: The Role of Angiotensin-Converting Enzyme 2 and the Renin-Angiotensin System. Adv Chronic Kidney Dis, 27(5), 404–411. https://doi.org/10.1053/j.ackd.2020.07.002
Edmonston, Daniel L., Andrew M. South, Matthew A. Sparks, and Jordana B. Cohen. “Coronavirus Disease 2019 and Hypertension: The Role of Angiotensin-Converting Enzyme 2 and the Renin-Angiotensin System.Adv Chronic Kidney Dis 27, no. 5 (September 2020): 404–11. https://doi.org/10.1053/j.ackd.2020.07.002.
Edmonston DL, South AM, Sparks MA, Cohen JB. Coronavirus Disease 2019 and Hypertension: The Role of Angiotensin-Converting Enzyme 2 and the Renin-Angiotensin System. Adv Chronic Kidney Dis. 2020 Sep;27(5):404–11.
Edmonston, Daniel L., et al. “Coronavirus Disease 2019 and Hypertension: The Role of Angiotensin-Converting Enzyme 2 and the Renin-Angiotensin System.Adv Chronic Kidney Dis, vol. 27, no. 5, Sept. 2020, pp. 404–11. Pubmed, doi:10.1053/j.ackd.2020.07.002.
Edmonston DL, South AM, Sparks MA, Cohen JB. Coronavirus Disease 2019 and Hypertension: The Role of Angiotensin-Converting Enzyme 2 and the Renin-Angiotensin System. Adv Chronic Kidney Dis. 2020 Sep;27(5):404–411.
Journal cover image

Published In

Adv Chronic Kidney Dis

DOI

EISSN

1548-5609

Publication Date

September 2020

Volume

27

Issue

5

Start / End Page

404 / 411

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Up-Regulation
  • SARS-CoV-2
  • Risk Factors
  • Renin-Angiotensin System
  • Receptors, Coronavirus
  • Protective Factors
  • Peptide Fragments
  • MAP Kinase Signaling System
  • Lung