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Relationship between neural functional connectivity and memory performance in age-related macular degeneration.

Publication ,  Journal Article
Zuo, X; Zhuang, J; Chen, N-K; Cousins, S; Cunha, P; Lad, EM; Madden, DJ; Potter, G; Whitson, HE
Published in: Neurobiol Aging
November 2020

Age-related macular degeneration (AMD) has been linked to memory deficits, with no established neural mechanisms. We collected resting-state brain functional magnetic resonance imaging and standardized verbal recall tests from 42 older adults with AMD and 41 age-matched controls. We used seed-based whole brain analysis to quantify the strength of functional connectivity between hubs of the default mode network and a network of medial temporal regions relevant for memory. Our results indicated neither memory performance nor network connectivity differed by AMD status. However, the AMD participants exhibited stronger relationships than the controls between memory performance and connectivity from the memory network hub (left parahippocampal) to 2 other regions: the left temporal pole and the right superior/middle frontal gyri. Also, the connectivity between the medial prefrontal cortex and posterior cingulate cortex of default mode network correlated more strongly with memory performance in AMD compared to control. We concluded that stronger brain-behavior correlation in AMD may suggest a role for region-specific connectivity in supporting memory in the context of AMD.

Duke Scholars

Published In

Neurobiol Aging

DOI

EISSN

1558-1497

Publication Date

November 2020

Volume

95

Start / End Page

176 / 185

Location

United States

Related Subject Headings

  • Neuropsychological Tests
  • Neurology & Neurosurgery
  • Neural Pathways
  • Mental Recall
  • Memory, Episodic
  • Memory Disorders
  • Male
  • Magnetic Resonance Imaging
  • Macular Degeneration
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zuo, X., Zhuang, J., Chen, N.-K., Cousins, S., Cunha, P., Lad, E. M., … Whitson, H. E. (2020). Relationship between neural functional connectivity and memory performance in age-related macular degeneration. Neurobiol Aging, 95, 176–185. https://doi.org/10.1016/j.neurobiolaging.2020.07.020
Zuo, Xintong, Jie Zhuang, Nan-Kuei Chen, Scott Cousins, Priscila Cunha, Eleonora M. Lad, David J. Madden, Guy Potter, and Heather E. Whitson. “Relationship between neural functional connectivity and memory performance in age-related macular degeneration.Neurobiol Aging 95 (November 2020): 176–85. https://doi.org/10.1016/j.neurobiolaging.2020.07.020.
Zuo X, Zhuang J, Chen N-K, Cousins S, Cunha P, Lad EM, et al. Relationship between neural functional connectivity and memory performance in age-related macular degeneration. Neurobiol Aging. 2020 Nov;95:176–85.
Zuo, Xintong, et al. “Relationship between neural functional connectivity and memory performance in age-related macular degeneration.Neurobiol Aging, vol. 95, Nov. 2020, pp. 176–85. Pubmed, doi:10.1016/j.neurobiolaging.2020.07.020.
Zuo X, Zhuang J, Chen N-K, Cousins S, Cunha P, Lad EM, Madden DJ, Potter G, Whitson HE. Relationship between neural functional connectivity and memory performance in age-related macular degeneration. Neurobiol Aging. 2020 Nov;95:176–185.
Journal cover image

Published In

Neurobiol Aging

DOI

EISSN

1558-1497

Publication Date

November 2020

Volume

95

Start / End Page

176 / 185

Location

United States

Related Subject Headings

  • Neuropsychological Tests
  • Neurology & Neurosurgery
  • Neural Pathways
  • Mental Recall
  • Memory, Episodic
  • Memory Disorders
  • Male
  • Magnetic Resonance Imaging
  • Macular Degeneration
  • Humans