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Clinicopathologic correlation of aniridia: Optical coherence tomography angiography and histopathologic observations.

Publication ,  Journal Article
Therattil, A; Naranjo, A; Hsu, ST; Kelly, MP; Freedman, SF; Dubovy, SR; Vajzovic, L
Published in: Am J Ophthalmol Case Rep
December 2020

PURPOSE: To describe optical coherence tomography angiography (OCTA) findings in a patient with aniridia and correlate with representative histopathology. OBSERVATIONS: OCTA images of the macula of a pediatric aniridic patient, who has nystagmus and impaired vision bilaterally, demonstrate a complete absence of the foveal avascular zone (FAZ) in both the superficial and deep vascular complexes (SVC and DVC). In addition, larger superficial blood vessels were found to be abnormally diving from the SVC into the DVC. Similarly, immunofluorescence with confocal microscopy imaging of a retinal histopathology specimen from a 2 month old aniridic patient demonstrated larger vessels diving in the same manner. CONCLUSIONS AND IMPORTANCE: This study highlights the clinical, imaging and histopathologic findings of aniridia. Supine OCTA imaging, performed during examination under anesthesia, allowed for visualization of retinal microvasculature in eyes with nystagmus. The histopathology images helped validate OCTA findings that, with further investigation, may lead to new information about the development of abnormal retinal microvasculature.

Duke Scholars

Published In

Am J Ophthalmol Case Rep

DOI

EISSN

2451-9936

Publication Date

December 2020

Volume

20

Start / End Page

100919

Location

United States
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Therattil, A., Naranjo, A., Hsu, S. T., Kelly, M. P., Freedman, S. F., Dubovy, S. R., & Vajzovic, L. (2020). Clinicopathologic correlation of aniridia: Optical coherence tomography angiography and histopathologic observations. Am J Ophthalmol Case Rep, 20, 100919. https://doi.org/10.1016/j.ajoc.2020.100919
Therattil, Anthony, Andrea Naranjo, S Tammy Hsu, Michael P. Kelly, Sharon F. Freedman, Sander R. Dubovy, and Lejla Vajzovic. “Clinicopathologic correlation of aniridia: Optical coherence tomography angiography and histopathologic observations.Am J Ophthalmol Case Rep 20 (December 2020): 100919. https://doi.org/10.1016/j.ajoc.2020.100919.
Therattil A, Naranjo A, Hsu ST, Kelly MP, Freedman SF, Dubovy SR, et al. Clinicopathologic correlation of aniridia: Optical coherence tomography angiography and histopathologic observations. Am J Ophthalmol Case Rep. 2020 Dec;20:100919.
Therattil, Anthony, et al. “Clinicopathologic correlation of aniridia: Optical coherence tomography angiography and histopathologic observations.Am J Ophthalmol Case Rep, vol. 20, Dec. 2020, p. 100919. Pubmed, doi:10.1016/j.ajoc.2020.100919.
Therattil A, Naranjo A, Hsu ST, Kelly MP, Freedman SF, Dubovy SR, Vajzovic L. Clinicopathologic correlation of aniridia: Optical coherence tomography angiography and histopathologic observations. Am J Ophthalmol Case Rep. 2020 Dec;20:100919.
Journal cover image

Published In

Am J Ophthalmol Case Rep

DOI

EISSN

2451-9936

Publication Date

December 2020

Volume

20

Start / End Page

100919

Location

United States