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Obesity Genomics and Metabolomics: a Nexus of Cardiometabolic Risk.

Publication ,  Journal Article
Regan, JA; Shah, SH
Published in: Curr Cardiol Rep
October 10, 2020

PURPOSE OF REVIEW: Obesity is a significant international public health epidemic with major downstream consequences on morbidity and mortality. While lifestyle factors contribute, there is an evolving understanding of genomic and metabolomic pathways involved with obesity and its relationship with cardiometabolic risk. This review will provide an overview of some of these important findings from both a biologic and clinical perspective. RECENT FINDINGS: Recent studies have identified polygenic risk scores and metabolomic biomarkers of obesity and related outcomes, which have also highlighted biological pathways, such as the branched-chain amino acid (BCAA) pathway that is dysregulated in this disease. These biomarkers may help in personalizing obesity interventions and for mitigation of future cardiometabolic risk. A multifaceted approach is necessary to impact the growing epidemic of obesity and related diseases. This will likely include incorporating precision medicine approaches with genomic and metabolomic biomarkers to personalize interventions and improve risk prediction.

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Published In

Curr Cardiol Rep

DOI

EISSN

1534-3170

Publication Date

October 10, 2020

Volume

22

Issue

12

Start / End Page

174

Location

United States

Related Subject Headings

  • Obesity
  • Metabolomics
  • Humans
  • Genomics
  • Cardiovascular System & Hematology
  • Cardiovascular Diseases
  • Biomarkers
  • Amino Acids, Branched-Chain
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology
 

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Regan, J. A., & Shah, S. H. (2020). Obesity Genomics and Metabolomics: a Nexus of Cardiometabolic Risk. Curr Cardiol Rep, 22(12), 174. https://doi.org/10.1007/s11886-020-01422-x
Regan, Jessica A., and Svati H. Shah. “Obesity Genomics and Metabolomics: a Nexus of Cardiometabolic Risk.Curr Cardiol Rep 22, no. 12 (October 10, 2020): 174. https://doi.org/10.1007/s11886-020-01422-x.
Regan JA, Shah SH. Obesity Genomics and Metabolomics: a Nexus of Cardiometabolic Risk. Curr Cardiol Rep. 2020 Oct 10;22(12):174.
Regan, Jessica A., and Svati H. Shah. “Obesity Genomics and Metabolomics: a Nexus of Cardiometabolic Risk.Curr Cardiol Rep, vol. 22, no. 12, Oct. 2020, p. 174. Pubmed, doi:10.1007/s11886-020-01422-x.
Regan JA, Shah SH. Obesity Genomics and Metabolomics: a Nexus of Cardiometabolic Risk. Curr Cardiol Rep. 2020 Oct 10;22(12):174.
Journal cover image

Published In

Curr Cardiol Rep

DOI

EISSN

1534-3170

Publication Date

October 10, 2020

Volume

22

Issue

12

Start / End Page

174

Location

United States

Related Subject Headings

  • Obesity
  • Metabolomics
  • Humans
  • Genomics
  • Cardiovascular System & Hematology
  • Cardiovascular Diseases
  • Biomarkers
  • Amino Acids, Branched-Chain
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology