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Vi-specific serological correlates of protection for typhoid fever.

Publication ,  Journal Article
Jin, C; Hill, J; Gunn, BM; Yu, W-H; Dahora, LC; Jones, E; Johnson, M; Gibani, MM; Spreng, RL; Alam, SM; Nebykova, A; Juel, HB; Dennison, SM ...
Published in: The Journal of experimental medicine
February 2021

Typhoid Vi vaccines have been shown to be efficacious in children living in endemic regions; however, a widely accepted correlate of protection remains to be established. We applied a systems serology approach to identify Vi-specific serological correlates of protection using samples obtained from participants enrolled in an experimental controlled human infection study. Participants were vaccinated with Vi-tetanus toxoid conjugate (Vi-TT) or unconjugated Vi-polysaccharide (Vi-PS) vaccines and were subsequently challenged with Salmonella Typhi bacteria. Multivariate analyses identified distinct protective signatures for Vi-TT and Vi-PS vaccines in addition to shared features that predicted protection across both groups. Vi IgA quantity and avidity correlated with protection from S. Typhi infection, whereas higher fold increases in Vi IgG responses were associated with reduced disease severity. Targeted antibody-mediated functional responses, particularly neutrophil phagocytosis, were also identified as important components of the protective signature. These humoral markers could be used to evaluate and develop efficacious Vi-conjugate vaccines and assist with accelerating vaccine availability to typhoid-endemic regions.

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Published In

The Journal of experimental medicine

DOI

EISSN

1540-9538

ISSN

0022-1007

Publication Date

February 2021

Volume

218

Issue

2

Start / End Page

e20201116

Related Subject Headings

  • Vaccines, Conjugate
  • Typhoid-Paratyphoid Vaccines
  • Typhoid Fever
  • Time Factors
  • Immunology
  • Immunoglobulin G
  • Immunogenicity, Vaccine
  • Immunity, Humoral
  • Humans
  • Bacterial Load
 

Citation

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MLA
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Jin, C., Hill, J., Gunn, B. M., Yu, W.-H., Dahora, L. C., Jones, E., … Pollard, A. J. (2021). Vi-specific serological correlates of protection for typhoid fever. The Journal of Experimental Medicine, 218(2), e20201116. https://doi.org/10.1084/jem.20201116
Jin, Celina, Jennifer Hill, Bronwyn M. Gunn, Wen-Han Yu, Lindsay C. Dahora, Elizabeth Jones, Mari Johnson, et al. “Vi-specific serological correlates of protection for typhoid fever.The Journal of Experimental Medicine 218, no. 2 (February 2021): e20201116. https://doi.org/10.1084/jem.20201116.
Jin C, Hill J, Gunn BM, Yu W-H, Dahora LC, Jones E, et al. Vi-specific serological correlates of protection for typhoid fever. The Journal of experimental medicine. 2021 Feb;218(2):e20201116.
Jin, Celina, et al. “Vi-specific serological correlates of protection for typhoid fever.The Journal of Experimental Medicine, vol. 218, no. 2, Feb. 2021, p. e20201116. Epmc, doi:10.1084/jem.20201116.
Jin C, Hill J, Gunn BM, Yu W-H, Dahora LC, Jones E, Johnson M, Gibani MM, Spreng RL, Alam SM, Nebykova A, Juel HB, Dennison SM, Seaton KE, Fallon JK, Tomaras GD, Alter G, Pollard AJ. Vi-specific serological correlates of protection for typhoid fever. The Journal of experimental medicine. 2021 Feb;218(2):e20201116.

Published In

The Journal of experimental medicine

DOI

EISSN

1540-9538

ISSN

0022-1007

Publication Date

February 2021

Volume

218

Issue

2

Start / End Page

e20201116

Related Subject Headings

  • Vaccines, Conjugate
  • Typhoid-Paratyphoid Vaccines
  • Typhoid Fever
  • Time Factors
  • Immunology
  • Immunoglobulin G
  • Immunogenicity, Vaccine
  • Immunity, Humoral
  • Humans
  • Bacterial Load