Sedative and Analgesic Pharmacokinetics During Pediatric ECMO.
Publication
, Journal Article
Zimmerman, KO; Dallefeld, SH; Hornik, CP; Watt, KM
Published in: J Pediatr Pharmacol Ther
2020
Sedatives and analgesics are often administered to critically ill children supported by extracorporeal membrane oxygenation (ECMO) to facilitate comfort and to decrease risks of life-threatening complications. Optimization of sedative and analgesic dosing is necessary to achieve desired therapeutic benefits and must consider interactions between the circuit and patient that may affect drug metabolism, clearance, and impact on target organs. This paper reviews existing in vitro and pediatric in vivo literature concerning the effects of the ECMO circuit on sedative and analgesic disposition and offers dosing guidance for the management of critically ill children receiving these drugs.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
J Pediatr Pharmacol Ther
DOI
ISSN
1551-6776
Publication Date
2020
Volume
25
Issue
8
Start / End Page
675 / 688
Location
United States
Related Subject Headings
- 3214 Pharmacology and pharmaceutical sciences
- 3213 Paediatrics
Citation
APA
Chicago
ICMJE
MLA
NLM
Zimmerman, K. O., Dallefeld, S. H., Hornik, C. P., & Watt, K. M. (2020). Sedative and Analgesic Pharmacokinetics During Pediatric ECMO. J Pediatr Pharmacol Ther, 25(8), 675–688. https://doi.org/10.5863/1551-6776-25.8.675
Zimmerman, Kanecia O., Samantha H. Dallefeld, Christoph P. Hornik, and Kevin M. Watt. “Sedative and Analgesic Pharmacokinetics During Pediatric ECMO.” J Pediatr Pharmacol Ther 25, no. 8 (2020): 675–88. https://doi.org/10.5863/1551-6776-25.8.675.
Zimmerman KO, Dallefeld SH, Hornik CP, Watt KM. Sedative and Analgesic Pharmacokinetics During Pediatric ECMO. J Pediatr Pharmacol Ther. 2020;25(8):675–88.
Zimmerman, Kanecia O., et al. “Sedative and Analgesic Pharmacokinetics During Pediatric ECMO.” J Pediatr Pharmacol Ther, vol. 25, no. 8, 2020, pp. 675–88. Pubmed, doi:10.5863/1551-6776-25.8.675.
Zimmerman KO, Dallefeld SH, Hornik CP, Watt KM. Sedative and Analgesic Pharmacokinetics During Pediatric ECMO. J Pediatr Pharmacol Ther. 2020;25(8):675–688.
Published In
J Pediatr Pharmacol Ther
DOI
ISSN
1551-6776
Publication Date
2020
Volume
25
Issue
8
Start / End Page
675 / 688
Location
United States
Related Subject Headings
- 3214 Pharmacology and pharmaceutical sciences
- 3213 Paediatrics