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Non-monotonic kilohertz frequency neural block thresholds arise from amplitude- and frequency-dependent charge imbalance.

Publication ,  Journal Article
Peña, E; Pelot, NA; Grill, WM
Published in: Scientific reports
March 2021

Reversible block of nerve conduction using kilohertz frequency electrical signals has substantial potential for treatment of disease. However, the ability to block nerve fibers selectively is limited by poor understanding of the relationship between waveform parameters and the nerve fibers that are blocked. Previous in vivo studies reported non-monotonic relationships between block signal frequency and block threshold, suggesting the potential for fiber-selective block. However, the mechanisms of non-monotonic block thresholds were unclear, and these findings were not replicated in a subsequent in vivo study. We used high-fidelity computational models and in vivo experiments in anesthetized rats to show that non-monotonic threshold-frequency relationships do occur, that they result from amplitude- and frequency-dependent charge imbalances that cause a shift between kilohertz frequency and direct current block regimes, and that these relationships can differ across fiber diameters such that smaller fibers can be blocked at lower thresholds than larger fibers. These results reconcile previous contradictory studies, clarify the mechanisms of interaction between kilohertz frequency and direct current block, and demonstrate the potential for selective block of small fiber diameters.

Duke Scholars

Published In

Scientific reports

DOI

EISSN

2045-2322

ISSN

2045-2322

Publication Date

March 2021

Volume

11

Issue

1

Start / End Page

5077

Related Subject Headings

  • Tibial Nerve
  • Rats, Sprague-Dawley
  • Rats
  • Neural Conduction
  • Nerve Fibers, Myelinated
  • Nerve Block
  • Models, Animal
  • Male
  • Electrodes
  • Electric Stimulation
 

Citation

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Peña, E., Pelot, N. A., & Grill, W. M. (2021). Non-monotonic kilohertz frequency neural block thresholds arise from amplitude- and frequency-dependent charge imbalance. Scientific Reports, 11(1), 5077. https://doi.org/10.1038/s41598-021-84503-3
Peña, Edgar, Nicole A. Pelot, and Warren M. Grill. “Non-monotonic kilohertz frequency neural block thresholds arise from amplitude- and frequency-dependent charge imbalance.Scientific Reports 11, no. 1 (March 2021): 5077. https://doi.org/10.1038/s41598-021-84503-3.
Peña, Edgar, et al. “Non-monotonic kilohertz frequency neural block thresholds arise from amplitude- and frequency-dependent charge imbalance.Scientific Reports, vol. 11, no. 1, Mar. 2021, p. 5077. Epmc, doi:10.1038/s41598-021-84503-3.

Published In

Scientific reports

DOI

EISSN

2045-2322

ISSN

2045-2322

Publication Date

March 2021

Volume

11

Issue

1

Start / End Page

5077

Related Subject Headings

  • Tibial Nerve
  • Rats, Sprague-Dawley
  • Rats
  • Neural Conduction
  • Nerve Fibers, Myelinated
  • Nerve Block
  • Models, Animal
  • Male
  • Electrodes
  • Electric Stimulation