PD-1 and PD-L1 expression in cardiac transplantation.
Publication
, Journal Article
Bishawi, M; Bowles, D; Pla, MM; Oakes, F; Chiang, Y; Schroder, J; Milano, C; Glass, C
Published in: Cardiovasc Pathol
2021
Programmed death-ligand 1 (PD-L1), a transmembrane protein and member of the CD28 T cell family is associated with lymphocyte activation.1 PD-L1 expression is upregulated on activated antigen presenting cells such as monocytes, myeloid and dendritic cells.2 When bound to its cognate receptor programmed cell death (PD-1), inhibition of immune responses including downregulation of T cell proliferation occurs.3 Mechanistically, such inhibition would be hypothetically favorable in the setting of a transplanted organ undergoing allograft rejection. However, there is a paucity of data addressing the role of PD-L1 and PD-1 expression in the human transplanted heart.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
Cardiovasc Pathol
DOI
EISSN
1879-1336
Publication Date
2021
Volume
54
Start / End Page
107331
Location
United States
Related Subject Headings
- T-Lymphocytes
- Programmed Cell Death 1 Receptor
- Lymphocyte Activation
- Humans
- Heart Transplantation
- Cardiovascular System & Hematology
- B7-H1 Antigen
- 3201 Cardiovascular medicine and haematology
- 1102 Cardiorespiratory Medicine and Haematology
Citation
APA
Chicago
ICMJE
MLA
NLM
Bishawi, M., Bowles, D., Pla, M. M., Oakes, F., Chiang, Y., Schroder, J., … Glass, C. (2021). PD-1 and PD-L1 expression in cardiac transplantation. Cardiovasc Pathol, 54, 107331. https://doi.org/10.1016/j.carpath.2021.107331
Bishawi, Muath, Dawn Bowles, Michelle Mendiola Pla, Faye Oakes, Yuting Chiang, Jacob Schroder, Carmelo Milano, and Carolyn Glass. “PD-1 and PD-L1 expression in cardiac transplantation.” Cardiovasc Pathol 54 (2021): 107331. https://doi.org/10.1016/j.carpath.2021.107331.
Bishawi M, Bowles D, Pla MM, Oakes F, Chiang Y, Schroder J, et al. PD-1 and PD-L1 expression in cardiac transplantation. Cardiovasc Pathol. 2021;54:107331.
Bishawi, Muath, et al. “PD-1 and PD-L1 expression in cardiac transplantation.” Cardiovasc Pathol, vol. 54, 2021, p. 107331. Pubmed, doi:10.1016/j.carpath.2021.107331.
Bishawi M, Bowles D, Pla MM, Oakes F, Chiang Y, Schroder J, Milano C, Glass C. PD-1 and PD-L1 expression in cardiac transplantation. Cardiovasc Pathol. 2021;54:107331.
Published In
Cardiovasc Pathol
DOI
EISSN
1879-1336
Publication Date
2021
Volume
54
Start / End Page
107331
Location
United States
Related Subject Headings
- T-Lymphocytes
- Programmed Cell Death 1 Receptor
- Lymphocyte Activation
- Humans
- Heart Transplantation
- Cardiovascular System & Hematology
- B7-H1 Antigen
- 3201 Cardiovascular medicine and haematology
- 1102 Cardiorespiratory Medicine and Haematology