Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Gulf War illness in the Gulf War Era Cohort and Biorepository: The Kansas and Centers for Disease Control definitions.

Publication ,  Journal Article
Gifford, EJ; Vahey, J; Hauser, ER; Sims, KJ; Efird, JT; Dursa, EK; Steele, L; Helmer, DA; Provenzale, D
Published in: Life Sci
August 1, 2021

AIMS: This study characterizes Gulf War Illness (GWI) among U.S. veterans who participated in the Gulf War Era Cohort and Biorepository (GWECB). MAIN METHODS: Mailed questionnaires were collected between 2014 and 2016. Self-reported GWI symptoms, symptom domain criteria, exclusionary diagnoses, and case status were examined based on the originally published Kansas and Centers for Disease Control (CDC) definitions in the GWECB cohort (n = 849 deployed to Gulf and n = 267 non-deployed). Associations among GWI and deployment status, demographic, and military service characteristics were examined using logistic regression. KEY FINDINGS: Among deployed veterans in our sample, 39.9% met the Kansas criteria and 84.2% met the CDC criteria for GWI. Relative to non-deployed veterans, deployed veterans had a higher odds of meeting four GWI case status-related measures including the Kansas symptom criteria (aOR = 2.05, 95% CI = 1.50, 2.80), Kansas GWI case status (aOR = 1.42, 95% CI = 1.05, 1.93), the CDC GWI case status (aOR = 1.57, 95% CI = 1.07, 2.29) and the CDC severe criteria (aOR = 2.67, 95% CI = 1.79, 3.99). Forty percent met the Kansas exclusionary criteria, with no difference by deployment status. Some symptoms were nearly universally endorsed. SIGNIFICANCE: This analysis provides evidence of a sustained, multisymptom illness in veterans who deployed to the Persian Gulf War compared to non-deployed Gulf War era veterans nearly 25 years later. Differences in symptoms attributed to GWI by deployment status have diminished since initial reports, suggesting the need to update GWI definitions to account for aging-related conditions and symptoms. This study provides a foundation for future efforts to establish a single GWI case definition and analyses that employ the biorepository.

Duke Scholars

Published In

Life Sci

DOI

EISSN

1879-0631

Publication Date

August 1, 2021

Volume

278

Start / End Page

119454

Location

Netherlands

Related Subject Headings

  • Veterans
  • United States
  • Symptom Assessment
  • Pharmacology & Pharmacy
  • Persian Gulf Syndrome
  • Military Personnel
  • Middle Aged
  • Male
  • Logistic Models
  • Kansas
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Gifford, E. J., Vahey, J., Hauser, E. R., Sims, K. J., Efird, J. T., Dursa, E. K., … Provenzale, D. (2021). Gulf War illness in the Gulf War Era Cohort and Biorepository: The Kansas and Centers for Disease Control definitions. Life Sci, 278, 119454. https://doi.org/10.1016/j.lfs.2021.119454
Gifford, Elizabeth J., Jacqueline Vahey, Elizabeth R. Hauser, Kellie J. Sims, Jimmy T. Efird, Erin K. Dursa, Lea Steele, Drew A. Helmer, and Dawn Provenzale. “Gulf War illness in the Gulf War Era Cohort and Biorepository: The Kansas and Centers for Disease Control definitions.Life Sci 278 (August 1, 2021): 119454. https://doi.org/10.1016/j.lfs.2021.119454.
Gifford EJ, Vahey J, Hauser ER, Sims KJ, Efird JT, Dursa EK, et al. Gulf War illness in the Gulf War Era Cohort and Biorepository: The Kansas and Centers for Disease Control definitions. Life Sci. 2021 Aug 1;278:119454.
Gifford, Elizabeth J., et al. “Gulf War illness in the Gulf War Era Cohort and Biorepository: The Kansas and Centers for Disease Control definitions.Life Sci, vol. 278, Aug. 2021, p. 119454. Pubmed, doi:10.1016/j.lfs.2021.119454.
Gifford EJ, Vahey J, Hauser ER, Sims KJ, Efird JT, Dursa EK, Steele L, Helmer DA, Provenzale D. Gulf War illness in the Gulf War Era Cohort and Biorepository: The Kansas and Centers for Disease Control definitions. Life Sci. 2021 Aug 1;278:119454.
Journal cover image

Published In

Life Sci

DOI

EISSN

1879-0631

Publication Date

August 1, 2021

Volume

278

Start / End Page

119454

Location

Netherlands

Related Subject Headings

  • Veterans
  • United States
  • Symptom Assessment
  • Pharmacology & Pharmacy
  • Persian Gulf Syndrome
  • Military Personnel
  • Middle Aged
  • Male
  • Logistic Models
  • Kansas