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Reactions to reduced nicotine content cigarettes in a sample of young adult, low-frequency smokers.

Publication ,  Journal Article
Sweitzer, MM; Pacek, LR; Kozink, RV; Locey, E; Kollins, SH; Donny, EC; McClernon, FJ
Published in: Psychopharmacology (Berl)
September 2021

RATIONALE: Reducing nicotine content in cigarettes to ≤ 2.4 mg per g of tobacco [mg/g] reduces smoking behavior and toxicant exposure among adult daily smokers. However, cigarettes with similar nicotine content could support continued experimentation and smoking progression among young adults who smoke infrequently. OBJECTIVES: This study evaluated the threshold for nicotine in cigarettes that produces reactions associated with smoking progression in a sample of young adults who smoke infrequently. METHODS: Young adults (n = 87, 18-25 years, 49% female) using tobacco products ≤ 15 days per month completed three counterbalanced, double-blinded sessions, each measuring positive and negative subjective reactions to fixed doses of smoke from investigational cigarettes containing one of three different nicotine contents: normal (NNC; 15.8 mg/g); very low (VLNC; 0.4 mg/g); and intermediate (INC; 2.4 mg/g). In a final session, participants chose one of the cigarettes to self-administer. RESULTS: Post-cigarette breath carbon monoxide was greater for VLNC than for NNC (p < 0.001). Positive reactions were greater for NNC than INC (p < 0.001) and for INC than VLNC (p = 0.001). Negative reactions were greater for NNC than INC and VLNC (both p < 0.001); INC and VLNC did not differ. Cigarette choices did not differ from an even distribution (43% NNC, 25% INC, 32% VLNC), but choice for NNC or INC was associated with higher ratio of positive to negative reactions during the NNC and INC fixed dose sessions, respectively (p < 0.001). CONCLUSIONS: Reducing nicotine content will likely lower the abuse liability of cigarettes for most young, low-frequency smokers. Additional work is needed to determine if compensatory smoking may lead to increased toxicant exposure, and if a subset of individuals choosing lower nicotine cigarettes may continue to smoke regardless of nicotine content.

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Published In

Psychopharmacology (Berl)

DOI

EISSN

1432-2072

Publication Date

September 2021

Volume

238

Issue

9

Start / End Page

2429 / 2438

Location

Germany

Related Subject Headings

  • Young Adult
  • Tobacco Products
  • Smoking Cessation
  • Smokers
  • Psychiatry
  • Pregnancy
  • Nicotine
  • Male
  • Infant
  • Humans
 

Citation

APA
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MLA
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Sweitzer, M. M., Pacek, L. R., Kozink, R. V., Locey, E., Kollins, S. H., Donny, E. C., & McClernon, F. J. (2021). Reactions to reduced nicotine content cigarettes in a sample of young adult, low-frequency smokers. Psychopharmacology (Berl), 238(9), 2429–2438. https://doi.org/10.1007/s00213-021-05864-1
Sweitzer, Maggie M., Lauren R. Pacek, Rachel V. Kozink, Erin Locey, Scott H. Kollins, Eric C. Donny, and F Joseph McClernon. “Reactions to reduced nicotine content cigarettes in a sample of young adult, low-frequency smokers.Psychopharmacology (Berl) 238, no. 9 (September 2021): 2429–38. https://doi.org/10.1007/s00213-021-05864-1.
Sweitzer MM, Pacek LR, Kozink RV, Locey E, Kollins SH, Donny EC, et al. Reactions to reduced nicotine content cigarettes in a sample of young adult, low-frequency smokers. Psychopharmacology (Berl). 2021 Sep;238(9):2429–38.
Sweitzer, Maggie M., et al. “Reactions to reduced nicotine content cigarettes in a sample of young adult, low-frequency smokers.Psychopharmacology (Berl), vol. 238, no. 9, Sept. 2021, pp. 2429–38. Pubmed, doi:10.1007/s00213-021-05864-1.
Sweitzer MM, Pacek LR, Kozink RV, Locey E, Kollins SH, Donny EC, McClernon FJ. Reactions to reduced nicotine content cigarettes in a sample of young adult, low-frequency smokers. Psychopharmacology (Berl). 2021 Sep;238(9):2429–2438.
Journal cover image

Published In

Psychopharmacology (Berl)

DOI

EISSN

1432-2072

Publication Date

September 2021

Volume

238

Issue

9

Start / End Page

2429 / 2438

Location

Germany

Related Subject Headings

  • Young Adult
  • Tobacco Products
  • Smoking Cessation
  • Smokers
  • Psychiatry
  • Pregnancy
  • Nicotine
  • Male
  • Infant
  • Humans