
Hypoxia signaling in renal pericytes-is it safe to activate?
Publication
, Journal Article
Herbek, S; Edmonston, DL; Souma, T
Published in: Kidney Int
June 2021
While excitement has grown for the use of hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors for treating renal anemia, multiple preclinical studies have shown the complex and cell-type-dependent roles of HIFs in kidney disease pathogenesis, including renal fibrosis. Pan et al. now clearly show that activating the HIF signaling in the Gli1-lineage myofibroblasts restores erythropoietin production while not adversely affecting matrix production, mitigating the concerns of exacerbated fibrosis by HIF prolyl hydroxylase inhibitors.
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Published In
Kidney Int
DOI
EISSN
1523-1755
Publication Date
June 2021
Volume
99
Issue
6
Start / End Page
1267 / 1269
Location
United States
Related Subject Headings
- Urology & Nephrology
- Renal Insufficiency, Chronic
- Prolyl-Hydroxylase Inhibitors
- Pericytes
- Kidney
- Hypoxia-Inducible Factor-Proline Dioxygenases
- Hypoxia
- Humans
- Fibrosis
- Erythropoiesis
Citation
APA
Chicago
ICMJE
MLA
NLM
Herbek, S., Edmonston, D. L., & Souma, T. (2021). Hypoxia signaling in renal pericytes-is it safe to activate? Kidney Int, 99(6), 1267–1269. https://doi.org/10.1016/j.kint.2021.02.014
Herbek, Savannah, Daniel L. Edmonston, and Tomokazu Souma. “Hypoxia signaling in renal pericytes-is it safe to activate?” Kidney Int 99, no. 6 (June 2021): 1267–69. https://doi.org/10.1016/j.kint.2021.02.014.
Herbek S, Edmonston DL, Souma T. Hypoxia signaling in renal pericytes-is it safe to activate? Kidney Int. 2021 Jun;99(6):1267–9.
Herbek, Savannah, et al. “Hypoxia signaling in renal pericytes-is it safe to activate?” Kidney Int, vol. 99, no. 6, June 2021, pp. 1267–69. Pubmed, doi:10.1016/j.kint.2021.02.014.
Herbek S, Edmonston DL, Souma T. Hypoxia signaling in renal pericytes-is it safe to activate? Kidney Int. 2021 Jun;99(6):1267–1269.

Published In
Kidney Int
DOI
EISSN
1523-1755
Publication Date
June 2021
Volume
99
Issue
6
Start / End Page
1267 / 1269
Location
United States
Related Subject Headings
- Urology & Nephrology
- Renal Insufficiency, Chronic
- Prolyl-Hydroxylase Inhibitors
- Pericytes
- Kidney
- Hypoxia-Inducible Factor-Proline Dioxygenases
- Hypoxia
- Humans
- Fibrosis
- Erythropoiesis