Skip to main content
release_alert
Welcome to the new Scholars 3.0! Read about new features and let us know what you think.
cancel
Journal cover image

Infective endocarditis and solid organ transplantation: Only worse outcomes during initial transplantation hospitalization.

Publication ,  Journal Article
Eichenberger, EM; Dagher, M; Sinclair, MR; Maskarinec, SA; Fowler, VG; Federspiel, JJ
Published in: American Heart Journal
October 2021

The epidemiology, and outcome of infective endocarditis (IE) among solid organ transplant (SOT) recipients is unknown.We used data from the 2013-2018 Nationwide Readmissions Database (NRD). IE- and SOT-associated hospitalizations were identified using diagnosis and procedure codes. Outcomes included inpatient mortality, length of stay, and inpatient costs. Adjusted analyses were performed using weighted regression models.A total of 99,052 IE-associated hospitalizations, corresponding to a weighted national estimate of 193,164, were included for analysis. Of these, 794 (weighted n = 1,574) were associated with transplant history (SOT-IE). Mortality was not significantly different between SOT-IE and non-SOT-IE (17.2% vs. 15.8%, adjusted relative risk [aRR]: 0.86, 95% confidence interval [CI] [0.71, 1.03]), and fewer SOT-IE patients underwent valve repair or replacement than non-SOT-IE (12.5% vs. 16.2%, aRR 0.82, 95% CI [0.71, 0.95]). We then compared outcomes of patients diagnosed with IE during their index transplant hospitalization (index-SOT-IE) to patients without IE during their transplant hospitalization (index-SOT). Index-SOT-IE occurred most frequently among heart transplant recipients (45.1%), and was associated with greater mortality (27.1% vs. 2.3%, aRR 6.07, 95% CI [3.32, 11.11]).Dual diagnosis of SOT and IE was associated with worse outcomes among SOT recipients during index hospitalization, but not overall among patients with IE.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

American Heart Journal

DOI

EISSN

1097-6744

ISSN

0002-8703

Publication Date

October 2021

Volume

240

Start / End Page

63 / 72

Related Subject Headings

  • United States
  • Treatment Outcome
  • Risk Factors
  • Retrospective Studies
  • Regression Analysis
  • Postoperative Complications
  • Organ Transplantation
  • Middle Aged
  • Male
  • Length of Stay
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Eichenberger, E. M., Dagher, M., Sinclair, M. R., Maskarinec, S. A., Fowler, V. G., & Federspiel, J. J. (2021). Infective endocarditis and solid organ transplantation: Only worse outcomes during initial transplantation hospitalization. American Heart Journal, 240, 63–72. https://doi.org/10.1016/j.ahj.2021.06.007
Eichenberger, Emily M., Michael Dagher, Matthew R. Sinclair, Stacey A. Maskarinec, Vance G. Fowler, and Jerome J. Federspiel. “Infective endocarditis and solid organ transplantation: Only worse outcomes during initial transplantation hospitalization.American Heart Journal 240 (October 2021): 63–72. https://doi.org/10.1016/j.ahj.2021.06.007.
Eichenberger EM, Dagher M, Sinclair MR, Maskarinec SA, Fowler VG, Federspiel JJ. Infective endocarditis and solid organ transplantation: Only worse outcomes during initial transplantation hospitalization. American Heart Journal. 2021 Oct;240:63–72.
Eichenberger, Emily M., et al. “Infective endocarditis and solid organ transplantation: Only worse outcomes during initial transplantation hospitalization.American Heart Journal, vol. 240, Oct. 2021, pp. 63–72. Epmc, doi:10.1016/j.ahj.2021.06.007.
Eichenberger EM, Dagher M, Sinclair MR, Maskarinec SA, Fowler VG, Federspiel JJ. Infective endocarditis and solid organ transplantation: Only worse outcomes during initial transplantation hospitalization. American Heart Journal. 2021 Oct;240:63–72.
Journal cover image

Published In

American Heart Journal

DOI

EISSN

1097-6744

ISSN

0002-8703

Publication Date

October 2021

Volume

240

Start / End Page

63 / 72

Related Subject Headings

  • United States
  • Treatment Outcome
  • Risk Factors
  • Retrospective Studies
  • Regression Analysis
  • Postoperative Complications
  • Organ Transplantation
  • Middle Aged
  • Male
  • Length of Stay