Skip to main content

Pharmacogenetic study in gastric cancer patients treated with adjuvant fluorouracil/leucovorin or epirubicin/cisplatin/fluorouracil before and after chemoradiation on CALGB 80101 (Alliance).

Publication ,  Journal Article
Patel, JN; Jiang, C; Owzar, K; Mulkey, F; Luzum, JA; Mamon, HJ; Haller, DG; Dragovich, T; Alberts, SR; Bjarnason, G; Willet, CG; Enzinger, P ...
Published in: Pharmacogenet Genomics
December 1, 2021

There is a lack of pharmacogenetic predictors of outcome in gastric cancer patients. The aim of this study was to assess previously identified candidate genes associated with 5-fluorouracil (5-FU), cisplatin, or epirubicin toxicity or response in a cohort of resected gastric cancer patients treated on CALGB (Alliance) 80101. Gastric or gastroesophageal cancer patients randomized to adjuvant 5-FU/leucovorin or epirubicin/cisplatin/5-FU before and after 5-FU chemoradiation were genotyped for single nucleotide polymorphisms (SNPs) in GSTP1 (rs1695), ERCC1 (rs11615 and rs3212986), XRCC1 (rs25487), UGT2B7 (rs7439366) and the 28 base-pair tandem repeats in TYMS (rs34743033). Logistic regression and log rank tests were used to assess the association between each SNP and incidence of grade 3/4 neutropenia and leukopenia, overall (OS) and progression-free survival (PFS), respectively. Toxicity endpoint analyses were adjusted for the treatment arm, while OS and PFS were also adjusted for performance status, sex, age, lymph node involvement, and primary tumor site and size. Of 281 subjects with successful genotyping results and available clinical (toxicity and efficacy) data, 166 self-reported non-Hispanic White patients were included in the final analysis. There was a lack of evidence of an association among any SNPs tested with grade 3/4 neutropenia and leukopenia or OS and PFS. Age, lymph node involvement, and primary tumor size were significantly associated with OS and PFS. This study failed to confirm results of previous gastric cancer pharmacogenetic studies.

Duke Scholars

Published In

Pharmacogenet Genomics

DOI

EISSN

1744-6880

Publication Date

December 1, 2021

Volume

31

Issue

9

Start / End Page

215 / 220

Location

United States

Related Subject Headings

  • X-ray Repair Cross Complementing Protein 1
  • Stomach Neoplasms
  • Pharmacology & Pharmacy
  • Pharmacogenomic Testing
  • Leucovorin
  • Humans
  • Fluorouracil
  • Epirubicin
  • Cisplatin
  • Antineoplastic Combined Chemotherapy Protocols
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Patel, J. N., Jiang, C., Owzar, K., Mulkey, F., Luzum, J. A., Mamon, H. J., … McLeod, H. L. (2021). Pharmacogenetic study in gastric cancer patients treated with adjuvant fluorouracil/leucovorin or epirubicin/cisplatin/fluorouracil before and after chemoradiation on CALGB 80101 (Alliance). Pharmacogenet Genomics, 31(9), 215–220. https://doi.org/10.1097/FPC.0000000000000442
Patel, Jai N., Chen Jiang, Kouros Owzar, Flora Mulkey, Jasmine A. Luzum, Harvey J. Mamon, Daniel G. Haller, et al. “Pharmacogenetic study in gastric cancer patients treated with adjuvant fluorouracil/leucovorin or epirubicin/cisplatin/fluorouracil before and after chemoradiation on CALGB 80101 (Alliance).Pharmacogenet Genomics 31, no. 9 (December 1, 2021): 215–20. https://doi.org/10.1097/FPC.0000000000000442.
Patel, Jai N., et al. “Pharmacogenetic study in gastric cancer patients treated with adjuvant fluorouracil/leucovorin or epirubicin/cisplatin/fluorouracil before and after chemoradiation on CALGB 80101 (Alliance).Pharmacogenet Genomics, vol. 31, no. 9, Dec. 2021, pp. 215–20. Pubmed, doi:10.1097/FPC.0000000000000442.
Patel JN, Jiang C, Owzar K, Mulkey F, Luzum JA, Mamon HJ, Haller DG, Dragovich T, Alberts SR, Bjarnason G, Willet CG, Niedzwiecki D, Enzinger P, Ratain MJ, Fuchs C, McLeod HL. Pharmacogenetic study in gastric cancer patients treated with adjuvant fluorouracil/leucovorin or epirubicin/cisplatin/fluorouracil before and after chemoradiation on CALGB 80101 (Alliance). Pharmacogenet Genomics. 2021 Dec 1;31(9):215–220.

Published In

Pharmacogenet Genomics

DOI

EISSN

1744-6880

Publication Date

December 1, 2021

Volume

31

Issue

9

Start / End Page

215 / 220

Location

United States

Related Subject Headings

  • X-ray Repair Cross Complementing Protein 1
  • Stomach Neoplasms
  • Pharmacology & Pharmacy
  • Pharmacogenomic Testing
  • Leucovorin
  • Humans
  • Fluorouracil
  • Epirubicin
  • Cisplatin
  • Antineoplastic Combined Chemotherapy Protocols