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Differential behavioral functioning in the offspring of rats with high vs. low self-administration of the opioid agonist remifentanil.

Publication ,  Journal Article
Rezvani, AH; Wells, C; Hawkey, A; Blair, G; Koburov, R; Ko, A; Schwartz, A; Kim, VJ; Levin, ED
Published in: Eur J Pharmacol
October 15, 2021

Opioid use disorder (OUD) has a variety of adverse effects on both the users and their offspring. In the current study, a random group of Sprague-Dawley rats (25 females and 15 males) were tested for intravenous self-administration of the opioid agonist remifentanil to determine the range of acquisition for opioid. One-month after the end of self-administration of remifentanil, rats with the highest intake were mated together and rats with lowest intake were mated together. Then, the offspring of the two groups were tested for anxiety-like behavior, locomotor activity, nociception and intravenous remifentanil self-administration. The parents showed a range of remifentanil self-administration, especially in the female rats. The offspring of the parents with low and high remifentanil self-administration showed significant differences in specific behavioral functions. On the hotplate test of nociception, the female offspring parents with high remifentanil self-administration had significantly longer hotplate latencies, indicating reduced nociception, than the female offspring of parents with low remifentanil-self-administration, whereas there was no difference in the male offspring of low and high responding parents. In the elevated plus maze test of anxiety-like behavior, the offspring of the parents with high remifentanil intake showed more anxiety-like behavior than the offspring of the parents with low remifentanil intake regardless of sex. Locomotor activity was not significantly different. Interestingly, no significant differences in remifentanil self-administration in the offspring of parents with low and high remifentanil self-administration were detected. Overall, our data suggest a considerable range in remifentanil self-administration in rats and the offspring of rats with high opioid self-administration exhibit different behaviors vs offspring of rats with low opioid self-administration.

Duke Scholars

Published In

Eur J Pharmacol

DOI

EISSN

1879-0712

Publication Date

October 15, 2021

Volume

909

Start / End Page

174407

Location

Netherlands

Related Subject Headings

  • Self Administration
  • Remifentanil
  • Rats
  • Pharmacology & Pharmacy
  • Paternal Exposure
  • Opioid-Related Disorders
  • Maternal Exposure
  • Male
  • Humans
  • Female
 

Citation

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ICMJE
MLA
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Rezvani, A. H., Wells, C., Hawkey, A., Blair, G., Koburov, R., Ko, A., … Levin, E. D. (2021). Differential behavioral functioning in the offspring of rats with high vs. low self-administration of the opioid agonist remifentanil. Eur J Pharmacol, 909, 174407. https://doi.org/10.1016/j.ejphar.2021.174407
Rezvani, Amir H., Corinne Wells, Andrew Hawkey, Graham Blair, Reese Koburov, Ashley Ko, Andrea Schwartz, Veronica J. Kim, and Edward D. Levin. “Differential behavioral functioning in the offspring of rats with high vs. low self-administration of the opioid agonist remifentanil.Eur J Pharmacol 909 (October 15, 2021): 174407. https://doi.org/10.1016/j.ejphar.2021.174407.
Rezvani AH, Wells C, Hawkey A, Blair G, Koburov R, Ko A, et al. Differential behavioral functioning in the offspring of rats with high vs. low self-administration of the opioid agonist remifentanil. Eur J Pharmacol. 2021 Oct 15;909:174407.
Rezvani, Amir H., et al. “Differential behavioral functioning in the offspring of rats with high vs. low self-administration of the opioid agonist remifentanil.Eur J Pharmacol, vol. 909, Oct. 2021, p. 174407. Pubmed, doi:10.1016/j.ejphar.2021.174407.
Rezvani AH, Wells C, Hawkey A, Blair G, Koburov R, Ko A, Schwartz A, Kim VJ, Levin ED. Differential behavioral functioning in the offspring of rats with high vs. low self-administration of the opioid agonist remifentanil. Eur J Pharmacol. 2021 Oct 15;909:174407.
Journal cover image

Published In

Eur J Pharmacol

DOI

EISSN

1879-0712

Publication Date

October 15, 2021

Volume

909

Start / End Page

174407

Location

Netherlands

Related Subject Headings

  • Self Administration
  • Remifentanil
  • Rats
  • Pharmacology & Pharmacy
  • Paternal Exposure
  • Opioid-Related Disorders
  • Maternal Exposure
  • Male
  • Humans
  • Female