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Perceptions of Exercise and Its Challenges in Patients With Nonalcoholic Fatty Liver Disease: A Survey-Based Study.

Publication ,  Journal Article
Glass, O; Liu, D; Bechard, E; Guy, CD; Pendergast, J; Mae Diehl, A; Abdelmalek, MF
Published in: Hepatology communications
February 2022

Exercise is a foundational treatment for nonalcoholic fatty liver disease (NAFLD); however, the majority of patients are unable to initiate and maintain effective exercise habits and remain at increased risk for progressive liver disease. Barriers and limitations to exercise in patients with NAFLD have not been fully identified. We performed a single survey of 94 patients with biopsy-proven NAFLD to understand baseline physical activity and sedentary behavior, self-perceived fitness, limitations to exercise, potential solutions to increase physical activity behavior, and perception of exercise as a foundational treatment for NAFLD. For exploratory analyses, we evaluated differences in responses to the survey by grouping severity of hepatic fibrosis as follows: nonalcoholic fatty liver (NAFL); early stage (nonalcoholic steatohepatitis [NASH] F0, NASH F1, NASH F2); and late stage (NASH F3, NASH F4). Zero weekly total physical activity was reported by 29% of patients with NAFLD. Late-stage NASH had significantly lower vigorous (P = 0.024), walking (P = 0.029), total weekly activity (P = 0.043), and current fitness level (P = 0.022) compared to early stage NASH. Overall, 72% of patients with NAFLD reported limitations to exercise, with the greatest proportion citing lack of energy (62%), fatigue (61%), prior/current Injury (50%), and shortness of breath (49%). A preference for personal training to increase their physical activity was indicated by 66% of patients with NAFLD, and 63% preferred exercise over medication to treat NAFLD. Conclusion: The majority of patients with NAFLD have limitations to exercise but prefer exercise as a treatment option for NAFLD in the form of personal training. Patients with NAFLD may have unique physiologic limitations to exercise that worsen with fibrosis severity. Exercise interventions or services that are personalized and scalable may improve sustainability of exercise habits in the long term.

Duke Scholars

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Published In

Hepatology communications

DOI

EISSN

2471-254X

ISSN

2471-254X

Publication Date

February 2022

Volume

6

Issue

2

Start / End Page

334 / 344

Related Subject Headings

  • Sedentary Behavior
  • Physical Fitness
  • Perception
  • Non-alcoholic Fatty Liver Disease
  • Middle Aged
  • Male
  • Humans
  • Health Surveys
  • Health Behavior
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Glass, O., Liu, D., Bechard, E., Guy, C. D., Pendergast, J., Mae Diehl, A., & Abdelmalek, M. F. (2022). Perceptions of Exercise and Its Challenges in Patients With Nonalcoholic Fatty Liver Disease: A Survey-Based Study. Hepatology Communications, 6(2), 334–344. https://doi.org/10.1002/hep4.1808
Glass, Oliver, Daniel Liu, Elizabeth Bechard, Cynthia D. Guy, Jane Pendergast, Anna Mae Diehl, and Manal F. Abdelmalek. “Perceptions of Exercise and Its Challenges in Patients With Nonalcoholic Fatty Liver Disease: A Survey-Based Study.Hepatology Communications 6, no. 2 (February 2022): 334–44. https://doi.org/10.1002/hep4.1808.
Glass O, Liu D, Bechard E, Guy CD, Pendergast J, Mae Diehl A, et al. Perceptions of Exercise and Its Challenges in Patients With Nonalcoholic Fatty Liver Disease: A Survey-Based Study. Hepatology communications. 2022 Feb;6(2):334–44.
Glass, Oliver, et al. “Perceptions of Exercise and Its Challenges in Patients With Nonalcoholic Fatty Liver Disease: A Survey-Based Study.Hepatology Communications, vol. 6, no. 2, Feb. 2022, pp. 334–44. Epmc, doi:10.1002/hep4.1808.
Glass O, Liu D, Bechard E, Guy CD, Pendergast J, Mae Diehl A, Abdelmalek MF. Perceptions of Exercise and Its Challenges in Patients With Nonalcoholic Fatty Liver Disease: A Survey-Based Study. Hepatology communications. 2022 Feb;6(2):334–344.

Published In

Hepatology communications

DOI

EISSN

2471-254X

ISSN

2471-254X

Publication Date

February 2022

Volume

6

Issue

2

Start / End Page

334 / 344

Related Subject Headings

  • Sedentary Behavior
  • Physical Fitness
  • Perception
  • Non-alcoholic Fatty Liver Disease
  • Middle Aged
  • Male
  • Humans
  • Health Surveys
  • Health Behavior
  • Female