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Transition to invasive breast cancer is associated with progressive changes in the structure and composition of tumor stroma.

Publication ,  Journal Article
Risom, T; Glass, DR; Averbukh, I; Liu, CC; Baranski, A; Kagel, A; McCaffrey, EF; Greenwald, NF; Rivero-Gutiérrez, B; Strand, SH; Varma, S ...
Published in: Cell
January 20, 2022

Ductal carcinoma in situ (DCIS) is a pre-invasive lesion that is thought to be a precursor to invasive breast cancer (IBC). To understand the changes in the tumor microenvironment (TME) accompanying transition to IBC, we used multiplexed ion beam imaging by time of flight (MIBI-TOF) and a 37-plex antibody staining panel to interrogate 79 clinically annotated surgical resections using machine learning tools for cell segmentation, pixel-based clustering, and object morphometrics. Comparison of normal breast with patient-matched DCIS and IBC revealed coordinated transitions between four TME states that were delineated based on the location and function of myoepithelium, fibroblasts, and immune cells. Surprisingly, myoepithelial disruption was more advanced in DCIS patients that did not develop IBC, suggesting this process could be protective against recurrence. Taken together, this HTAN Breast PreCancer Atlas study offers insight into drivers of IBC relapse and emphasizes the importance of the TME in regulating these processes.

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Published In

Cell

DOI

EISSN

1097-4172

Publication Date

January 20, 2022

Volume

185

Issue

2

Start / End Page

299 / 310.e18

Location

United States

Related Subject Headings

  • Tumor Microenvironment
  • Stromal Cells
  • Single-Cell Analysis
  • Phenotype
  • Neoplasm Recurrence, Local
  • Neoplasm Invasiveness
  • Middle Aged
  • Humans
  • Fibroblasts
  • Female
 

Citation

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Risom, T., Glass, D. R., Averbukh, I., Liu, C. C., Baranski, A., Kagel, A., … Angelo, M. (2022). Transition to invasive breast cancer is associated with progressive changes in the structure and composition of tumor stroma. Cell, 185(2), 299-310.e18. https://doi.org/10.1016/j.cell.2021.12.023
Risom, Tyler, David R. Glass, Inna Averbukh, Candace C. Liu, Alex Baranski, Adam Kagel, Erin F. McCaffrey, et al. “Transition to invasive breast cancer is associated with progressive changes in the structure and composition of tumor stroma.Cell 185, no. 2 (January 20, 2022): 299-310.e18. https://doi.org/10.1016/j.cell.2021.12.023.
Risom T, Glass DR, Averbukh I, Liu CC, Baranski A, Kagel A, et al. Transition to invasive breast cancer is associated with progressive changes in the structure and composition of tumor stroma. Cell. 2022 Jan 20;185(2):299-310.e18.
Risom, Tyler, et al. “Transition to invasive breast cancer is associated with progressive changes in the structure and composition of tumor stroma.Cell, vol. 185, no. 2, Jan. 2022, pp. 299-310.e18. Pubmed, doi:10.1016/j.cell.2021.12.023.
Risom T, Glass DR, Averbukh I, Liu CC, Baranski A, Kagel A, McCaffrey EF, Greenwald NF, Rivero-Gutiérrez B, Strand SH, Varma S, Kong A, Keren L, Srivastava S, Zhu C, Khair Z, Veis DJ, Deschryver K, Vennam S, Maley C, Hwang ES, Marks JR, Bendall SC, Colditz GA, West RB, Angelo M. Transition to invasive breast cancer is associated with progressive changes in the structure and composition of tumor stroma. Cell. 2022 Jan 20;185(2):299-310.e18.

Published In

Cell

DOI

EISSN

1097-4172

Publication Date

January 20, 2022

Volume

185

Issue

2

Start / End Page

299 / 310.e18

Location

United States

Related Subject Headings

  • Tumor Microenvironment
  • Stromal Cells
  • Single-Cell Analysis
  • Phenotype
  • Neoplasm Recurrence, Local
  • Neoplasm Invasiveness
  • Middle Aged
  • Humans
  • Fibroblasts
  • Female