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Modulation of microbial community dynamics by spatial partitioning.

Publication ,  Journal Article
Wu, F; Ha, Y; Weiss, A; Wang, M; Letourneau, J; Wang, S; Luo, N; Huang, S; Lee, CT; David, LA; You, L
Published in: Nat Chem Biol
April 2022

Microbial communities inhabit spatial architectures that divide a global environment into isolated or semi-isolated local environments, which leads to the partitioning of a microbial community into a collection of local communities. Despite its ubiquity and great interest in related processes, how and to what extent spatial partitioning affects the structures and dynamics of microbial communities are poorly understood. Using modeling and quantitative experiments with simple and complex microbial communities, we demonstrate that spatial partitioning modulates the community dynamics by altering the local interaction types and global interaction strength. Partitioning promotes the persistence of populations with negative interactions but suppresses those with positive interactions. For a community consisting of populations with both positive and negative interactions, an intermediate level of partitioning maximizes the overall diversity of the community. Our results reveal a general mechanism underlying the maintenance of microbial diversity and have implications for natural and engineered communities.

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Published In

Nat Chem Biol

DOI

EISSN

1552-4469

Publication Date

April 2022

Volume

18

Issue

4

Start / End Page

394 / 402

Location

United States

Related Subject Headings

  • Microbiota
  • Biochemistry & Molecular Biology
  • 3404 Medicinal and biomolecular chemistry
  • 3101 Biochemistry and cell biology
  • 0601 Biochemistry and Cell Biology
  • 0304 Medicinal and Biomolecular Chemistry
 

Citation

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Wu, F., Ha, Y., Weiss, A., Wang, M., Letourneau, J., Wang, S., … You, L. (2022). Modulation of microbial community dynamics by spatial partitioning. Nat Chem Biol, 18(4), 394–402. https://doi.org/10.1038/s41589-021-00961-w
Wu, Feilun, Yuanchi Ha, Andrea Weiss, Meidi Wang, Jeffrey Letourneau, Shangying Wang, Nan Luo, et al. “Modulation of microbial community dynamics by spatial partitioning.Nat Chem Biol 18, no. 4 (April 2022): 394–402. https://doi.org/10.1038/s41589-021-00961-w.
Wu F, Ha Y, Weiss A, Wang M, Letourneau J, Wang S, et al. Modulation of microbial community dynamics by spatial partitioning. Nat Chem Biol. 2022 Apr;18(4):394–402.
Wu, Feilun, et al. “Modulation of microbial community dynamics by spatial partitioning.Nat Chem Biol, vol. 18, no. 4, Apr. 2022, pp. 394–402. Pubmed, doi:10.1038/s41589-021-00961-w.
Wu F, Ha Y, Weiss A, Wang M, Letourneau J, Wang S, Luo N, Huang S, Lee CT, David LA, You L. Modulation of microbial community dynamics by spatial partitioning. Nat Chem Biol. 2022 Apr;18(4):394–402.

Published In

Nat Chem Biol

DOI

EISSN

1552-4469

Publication Date

April 2022

Volume

18

Issue

4

Start / End Page

394 / 402

Location

United States

Related Subject Headings

  • Microbiota
  • Biochemistry & Molecular Biology
  • 3404 Medicinal and biomolecular chemistry
  • 3101 Biochemistry and cell biology
  • 0601 Biochemistry and Cell Biology
  • 0304 Medicinal and Biomolecular Chemistry