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Development of Neutralization Breadth against Diverse HIV-1 by Increasing Ab-Ag Interface on V2.

Publication ,  Journal Article
Gao, N; Gai, Y; Meng, L; Wang, C; Wang, W; Li, X; Gu, T; Louder, MK; Doria-Rose, NA; Wiehe, K; Nazzari, AF; Olia, AS; Gorman, J; Rawi, R ...
Published in: Adv Sci (Weinh)
May 2022
Published version (DOI) Link to item

Understanding maturation pathways of broadly neutralizing antibodies (bnAbs) against HIV-1 can be highly informative for HIV-1 vaccine development. A lineage of J038 bnAbs is now obtained from a long-term SHIV-infected macaque. J038 neutralizes 54% of global circulating HIV-1 strains. Its binding induces a unique "up" conformation for one of the V2 loops in the trimeric envelope glycoprotein and is heavily dependent on glycan, which provides nearly half of the binding surface. Their unmutated common ancestor neutralizes the autologous virus. Continuous maturation enhances neutralization potency and breadth of J038 lineage antibodies via expanding antibody-Env contact areas surrounding the core region contacted by germline-encoded residues. Developmental details and recognition features of J038 lineage antibodies revealed here provide a new pathway for elicitation and maturation of V2-targeting bnAbs.

Duke Scholars

Kevin J Wiehe
Author Kevin J Wiehe Medicine, Duke Human Vaccine Institute
Feng Gao
Author Feng Gao Medicine, Infectious Diseases
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Published In

Adv Sci (Weinh)

DOI

10.1002/advs.202200063

EISSN

2198-3844

Publication Date

May 2022

Volume

9

Issue

15

Start / End Page

e2200063

Location

Germany

Related Subject Headings

  • env Gene Products, Human Immunodeficiency Virus
  • Humans
  • HIV-1
  • HIV Seropositivity
  • HIV Infections
  • HIV Antibodies
  • Epitopes
  • Broadly Neutralizing Antibodies
  • Antibodies, Neutralizing
 

Citation

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ICMJE
MLA
NLM
Gao, N., Gai, Y., Meng, L., Wang, C., Wang, W., Li, X., … Gao, F. (2022). Development of Neutralization Breadth against Diverse HIV-1 by Increasing Ab-Ag Interface on V2. Adv Sci (Weinh), 9(15), e2200063. https://doi.org/10.1002/advs.202200063
Gao, Nan, Yanxin Gai, Lina Meng, Chu Wang, Wei Wang, Xiaojun Li, Tiejun Gu, et al. “Development of Neutralization Breadth against Diverse HIV-1 by Increasing Ab-Ag Interface on V2.” Adv Sci (Weinh) 9, no. 15 (May 2022): e2200063. https://doi.org/10.1002/advs.202200063.
Gao N, Gai Y, Meng L, Wang C, Wang W, Li X, et al. Development of Neutralization Breadth against Diverse HIV-1 by Increasing Ab-Ag Interface on V2. Adv Sci (Weinh). 2022 May;9(15):e2200063.
Gao, Nan, et al. “Development of Neutralization Breadth against Diverse HIV-1 by Increasing Ab-Ag Interface on V2.” Adv Sci (Weinh), vol. 9, no. 15, May 2022, p. e2200063. Pubmed, doi:10.1002/advs.202200063.
Gao N, Gai Y, Meng L, Wang C, Wang W, Li X, Gu T, Louder MK, Doria-Rose NA, Wiehe K, Nazzari AF, Olia AS, Gorman J, Rawi R, Wu W, Smith C, Khant H, de Val N, Yu B, Luo J, Niu H, Tsybovsky Y, Liao H, Kepler TB, Kwong PD, Mascola JR, Qin C, Zhou T, Yu X, Gao F. Development of Neutralization Breadth against Diverse HIV-1 by Increasing Ab-Ag Interface on V2. Adv Sci (Weinh). 2022 May;9(15):e2200063.
Journal cover image

Published In

Adv Sci (Weinh)

DOI

10.1002/advs.202200063

EISSN

2198-3844

Publication Date

May 2022

Volume

9

Issue

15

Start / End Page

e2200063

Location

Germany

Related Subject Headings

  • env Gene Products, Human Immunodeficiency Virus
  • Humans
  • HIV-1
  • HIV Seropositivity
  • HIV Infections
  • HIV Antibodies
  • Epitopes
  • Broadly Neutralizing Antibodies
  • Antibodies, Neutralizing