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Glycemic status, non-traditional risk and left ventricular structure and function in the Jackson Heart Study.

Publication ,  Journal Article
Ani, C; Shavlik, D; Knutsen, S; Abudayyeh, I; Banta, J; O'Brien, E; Mentz, RJ; Bertoni, AG; Fraser, G
Published in: BMC cardiovascular disorders
April 2022

Left ventricular structure and function abnormalities may be an early marker of cardiomyopathy among African Americans with diabetes (DM) even in the absence of coronary artery disease (CAD), arrhythmia, valvular heart disease and end-stage renal disease (ESRD). This study examined the association of prediabetes (PDM), DM and HbA1c with left ventricular structure and function among Jackson Heart Study (JHS) participants without traditional risk factors.Retrospective cross-sectional analyses of the association of PDM, DM and HbA1c with, left ventricular ejection fraction (LV EF), fractional shortening (LV FS), stroke volume index (SVI), cardiac index (CI), left ventricular end diastolic volume index (LVEDVI), left ventricular end systolic volume index (LVESVI), relative wall thickness (RWT), myocardial contraction fraction (MCF) and left ventricular mass index (LVMI). The study was conducted in 2234 adult JHS participants without preexisting CAD, arrhythmia, valvular heart disease or ESRD. Statistical analyses included descriptive, univariate and covariate adjusted linear regression analyses. Sensitivity analyses to explore the impact of hypertension on study outcomes were also carried out.DM compared with no DM was associated with lower, SVI (- 0.96 ml/m2, p = 0.029), LVEDVI (- 1.44 ml/m2 p = 0.015), and MCF (- 1.90% p = 0.007) but higher CI (0.14 L/min/m2, p < 0.001), RWT (0.01 cm, p = 0.002) and LVMI (2.29 g/m2, p = 0.009). After further control for DM duration, only CI remaining significantly higher for DM compared with no DM participants (0.12 L/min/m2, p = 0.009). PDM compared with no PDM was associated with lower, SVI (- 0.87 ml/m2, P = 0.024), LVEDVI (- 1.15 ml/m2 p = 0.003) and LVESVI (- 0.62 ml/m2 p = 0.025). HbA1c ≥ 8.0% compared with HbA1c < 5.7% was associated with lower SVI (- 2.09 ml/m2, p = 0.004), LVEDVI (- 2.11 ml/m2 p = 0.032) and MCF (- 2.94% p = 0.011) but higher CI (0.11 L/min/m2, p = 0.043) and RWT (0.01 cm, p = 0.035).Glycemic status is associated with important left ventricular structure and function changes among African Americans without prior CAD, arrhythmia, valvular heart disease and ESRD. Longitudinal studies may further elucidate these relationships.

Duke Scholars

Published In

BMC cardiovascular disorders

DOI

EISSN

1471-2261

ISSN

1471-2261

Publication Date

April 2022

Volume

22

Issue

1

Start / End Page

186

Related Subject Headings

  • Ventricular Function, Left
  • Stroke Volume
  • Retrospective Studies
  • Male
  • Longitudinal Studies
  • Kidney Failure, Chronic
  • Humans
  • Heart Valve Diseases
  • Glycated Hemoglobin
  • Female
 

Citation

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Chicago
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Ani, C., Shavlik, D., Knutsen, S., Abudayyeh, I., Banta, J., O’Brien, E., … Fraser, G. (2022). Glycemic status, non-traditional risk and left ventricular structure and function in the Jackson Heart Study. BMC Cardiovascular Disorders, 22(1), 186. https://doi.org/10.1186/s12872-022-02605-w
Ani, Chizobam, David Shavlik, Synnove Knutsen, Islam Abudayyeh, Jimmie Banta, Emily O’Brien, Robert J. Mentz, Alain G. Bertoni, and Gary Fraser. “Glycemic status, non-traditional risk and left ventricular structure and function in the Jackson Heart Study.BMC Cardiovascular Disorders 22, no. 1 (April 2022): 186. https://doi.org/10.1186/s12872-022-02605-w.
Ani C, Shavlik D, Knutsen S, Abudayyeh I, Banta J, O’Brien E, et al. Glycemic status, non-traditional risk and left ventricular structure and function in the Jackson Heart Study. BMC cardiovascular disorders. 2022 Apr;22(1):186.
Ani, Chizobam, et al. “Glycemic status, non-traditional risk and left ventricular structure and function in the Jackson Heart Study.BMC Cardiovascular Disorders, vol. 22, no. 1, Apr. 2022, p. 186. Epmc, doi:10.1186/s12872-022-02605-w.
Ani C, Shavlik D, Knutsen S, Abudayyeh I, Banta J, O’Brien E, Mentz RJ, Bertoni AG, Fraser G. Glycemic status, non-traditional risk and left ventricular structure and function in the Jackson Heart Study. BMC cardiovascular disorders. 2022 Apr;22(1):186.
Journal cover image

Published In

BMC cardiovascular disorders

DOI

EISSN

1471-2261

ISSN

1471-2261

Publication Date

April 2022

Volume

22

Issue

1

Start / End Page

186

Related Subject Headings

  • Ventricular Function, Left
  • Stroke Volume
  • Retrospective Studies
  • Male
  • Longitudinal Studies
  • Kidney Failure, Chronic
  • Humans
  • Heart Valve Diseases
  • Glycated Hemoglobin
  • Female