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Persistent post-COVID-19 smell loss is associated with inflammatory infiltration and altered olfactory epithelial gene expression.

Publication ,  Journal Article
Finlay, JB; Brann, DH; Abi-Hachem, R; Jang, DW; Oliva, AD; Ko, T; Gupta, R; Wellford, SA; Moseman, EA; Jang, SS; Yan, CH; Matusnami, H ...
Published in: bioRxiv
April 18, 2022

Most human subjects infected by SARS-CoV-2 report an acute alteration in their sense of smell, and more than 25% of COVID patients report lasting olfactory dysfunction. While animal studies and human autopsy tissues have suggested mechanisms underlying acute loss of smell, the pathophysiology that underlies persistent smell loss remains unclear. Here we combine objective measurements of smell loss in patients suffering from post-acute sequelae of SARS-CoV-2 infection (PASC) with single cell sequencing and histology of the olfactory epithelium (OE). This approach reveals that the OE of patients with persistent smell loss harbors a diffuse infiltrate of T cells expressing interferon-gamma; gene expression in sustentacular cells appears to reflect a response to inflammatory signaling, which is accompanied by a reduction in the number of olfactory sensory neurons relative to support cells. These data identify a persistent epithelial inflammatory process associated with PASC, and suggests mechanisms through which this T cell-mediated inflammation alters the sense of smell.

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Published In

bioRxiv

DOI

EISSN

2692-8205

Publication Date

April 18, 2022

Location

United States
 

Citation

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Finlay, J. B., Brann, D. H., Abi-Hachem, R., Jang, D. W., Oliva, A. D., Ko, T., … Goldstein, B. J. (2022). Persistent post-COVID-19 smell loss is associated with inflammatory infiltration and altered olfactory epithelial gene expression. BioRxiv. https://doi.org/10.1101/2022.04.17.488474
Finlay, John B., David H. Brann, Ralph Abi-Hachem, David W. Jang, Allison D. Oliva, Tiffany Ko, Rupali Gupta, et al. “Persistent post-COVID-19 smell loss is associated with inflammatory infiltration and altered olfactory epithelial gene expression.BioRxiv, April 18, 2022. https://doi.org/10.1101/2022.04.17.488474.
Finlay JB, Brann DH, Abi-Hachem R, Jang DW, Oliva AD, Ko T, et al. Persistent post-COVID-19 smell loss is associated with inflammatory infiltration and altered olfactory epithelial gene expression. bioRxiv. 2022 Apr 18;
Finlay, John B., et al. “Persistent post-COVID-19 smell loss is associated with inflammatory infiltration and altered olfactory epithelial gene expression.BioRxiv, Apr. 2022. Pubmed, doi:10.1101/2022.04.17.488474.
Finlay JB, Brann DH, Abi-Hachem R, Jang DW, Oliva AD, Ko T, Gupta R, Wellford SA, Moseman EA, Jang SS, Yan CH, Matusnami H, Tsukahara T, Datta SR, Goldstein BJ. Persistent post-COVID-19 smell loss is associated with inflammatory infiltration and altered olfactory epithelial gene expression. bioRxiv. 2022 Apr 18;

Published In

bioRxiv

DOI

EISSN

2692-8205

Publication Date

April 18, 2022

Location

United States