Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Longitudinal assessment of colonoscopy adverse events in the prospective Cooperative Studies Program no. 380 colorectal cancer screening and surveillance cohort.

Publication ,  Journal Article
Kobe, EA; Sullivan, BA; Qin, X; Redding, TS; Hauser, ER; Madison, AN; Miller, C; Efird, JT; Gellad, ZF; Weiss, D; Sims, KJ; Williams, CD ...
Published in: Gastrointest Endosc
September 2022

BACKGROUND AND AIMS: Data are limited regarding colonoscopy risk during long-term, programmatic colorectal cancer screening and follow-up. We aimed to describe adverse events during follow-up in a colonoscopy screening program after the baseline examination and examine factors associated with increased risk. METHODS: Cooperative Studies Program no. 380 includes 3121 asymptomatic veterans aged 50 to 75 years who underwent screening colonoscopy between 1994 and 1997. Periprocedure adverse events requiring significant intervention were defined as major events (other events were minor) and were tracked during follow-up for at least 10 years. Multivariable odds ratios (ORs) were calculated for factors associated with risk of follow-up adverse events. RESULTS: Of 3727 follow-up examinations in 1983 participants, adverse events occurred in 105 examinations (2.8%) in 93 individuals, including 22 major and 87 minor events (examinations may have had >1 event). Incidence of major events (per 1000 examinations) remained relatively stable over time, with 6.1 events at examination 2, 4.8 at examination 3, and 7.2 at examination 4. Examinations with major events included 1 perforation, 3 GI bleeds requiring intervention, and 17 cardiopulmonary events. History of prior colonoscopic adverse events was associated with increased risk of events (major or minor) during follow-up (OR, 2.7; 95% confidence interval, 1.6-4.6). CONCLUSIONS: Long-term programmatic screening and surveillance was safe, as major events were rare during follow-up. However, serious cardiopulmonary events were the most common major events. These results highlight the need for detailed assessments of comorbid conditions during routine clinical practice, which could help inform individual decisions regarding the utility of ongoing colonoscopy follow-up.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Gastrointest Endosc

DOI

EISSN

1097-6779

Publication Date

September 2022

Volume

96

Issue

3

Start / End Page

553 / 562.e3

Location

United States

Related Subject Headings

  • Risk Factors
  • Prospective Studies
  • Mass Screening
  • Humans
  • Gastroenterology & Hepatology
  • Early Detection of Cancer
  • Colorectal Neoplasms
  • Colonoscopy
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kobe, E. A., Sullivan, B. A., Qin, X., Redding, T. S., Hauser, E. R., Madison, A. N., … Provenzale, D. (2022). Longitudinal assessment of colonoscopy adverse events in the prospective Cooperative Studies Program no. 380 colorectal cancer screening and surveillance cohort. Gastrointest Endosc, 96(3), 553-562.e3. https://doi.org/10.1016/j.gie.2022.04.1343
Kobe, Elizabeth A., Brian A. Sullivan, Xuejun Qin, Thomas S. Redding, Elizabeth R. Hauser, Ashton N. Madison, Cameron Miller, et al. “Longitudinal assessment of colonoscopy adverse events in the prospective Cooperative Studies Program no. 380 colorectal cancer screening and surveillance cohort.Gastrointest Endosc 96, no. 3 (September 2022): 553-562.e3. https://doi.org/10.1016/j.gie.2022.04.1343.
Kobe EA, Sullivan BA, Qin X, Redding TS, Hauser ER, Madison AN, et al. Longitudinal assessment of colonoscopy adverse events in the prospective Cooperative Studies Program no. 380 colorectal cancer screening and surveillance cohort. Gastrointest Endosc. 2022 Sep;96(3):553-562.e3.
Kobe, Elizabeth A., et al. “Longitudinal assessment of colonoscopy adverse events in the prospective Cooperative Studies Program no. 380 colorectal cancer screening and surveillance cohort.Gastrointest Endosc, vol. 96, no. 3, Sept. 2022, pp. 553-562.e3. Pubmed, doi:10.1016/j.gie.2022.04.1343.
Kobe EA, Sullivan BA, Qin X, Redding TS, Hauser ER, Madison AN, Miller C, Efird JT, Gellad ZF, Weiss D, Sims KJ, Williams CD, Lieberman DA, Provenzale D. Longitudinal assessment of colonoscopy adverse events in the prospective Cooperative Studies Program no. 380 colorectal cancer screening and surveillance cohort. Gastrointest Endosc. 2022 Sep;96(3):553-562.e3.
Journal cover image

Published In

Gastrointest Endosc

DOI

EISSN

1097-6779

Publication Date

September 2022

Volume

96

Issue

3

Start / End Page

553 / 562.e3

Location

United States

Related Subject Headings

  • Risk Factors
  • Prospective Studies
  • Mass Screening
  • Humans
  • Gastroenterology & Hepatology
  • Early Detection of Cancer
  • Colorectal Neoplasms
  • Colonoscopy
  • 3202 Clinical sciences
  • 1103 Clinical Sciences