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Estrogen Receptor Signaling in the Immune System.

Publication ,  Journal Article
Chakraborty, B; Byemerwa, J; Krebs, T; Lim, F; Chang, C-Y; McDonnell, DP
Published in: Endocr Rev
January 12, 2023

The immune system functions in a sexually dimorphic manner, with females exhibiting more robust immune responses than males. However, how female sex hormones affect immune function in normal homeostasis and in autoimmunity is poorly understood. In this review, we discuss how estrogens affect innate and adaptive immune cell activity and how dysregulation of estrogen signaling underlies the pathobiology of some autoimmune diseases and cancers. The potential roles of the major circulating estrogens, and each of the 3 estrogen receptors (ERα, ERβ, and G-protein coupled receptor) in the regulation of the activity of different immune cells are considered. This provides the framework for a discussion of the impact of ER modulators (aromatase inhibitors, selective estrogen receptor modulators, and selective estrogen receptor downregulators) on immunity. Synthesis of this information is timely given the considerable interest of late in defining the mechanistic basis of sex-biased responses/outcomes in patients with different cancers treated with immune checkpoint blockade. It will also be instructive with respect to the further development of ER modulators that modulate immunity in a therapeutically useful manner.

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Published In

Endocr Rev

DOI

EISSN

1945-7189

Publication Date

January 12, 2023

Volume

44

Issue

1

Start / End Page

117 / 141

Location

United States

Related Subject Headings

  • Selective Estrogen Receptor Modulators
  • Receptors, Estrogen
  • Male
  • Immune System
  • Humans
  • Female
  • Estrogens
  • Estrogen Receptor beta
  • Estrogen Receptor alpha
  • Estradiol
 

Citation

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Chakraborty, B., Byemerwa, J., Krebs, T., Lim, F., Chang, C.-Y., & McDonnell, D. P. (2023). Estrogen Receptor Signaling in the Immune System. Endocr Rev, 44(1), 117–141. https://doi.org/10.1210/endrev/bnac017
Chakraborty, Binita, Jovita Byemerwa, Taylor Krebs, Felicia Lim, Ching-Yi Chang, and Donald P. McDonnell. “Estrogen Receptor Signaling in the Immune System.Endocr Rev 44, no. 1 (January 12, 2023): 117–41. https://doi.org/10.1210/endrev/bnac017.
Chakraborty B, Byemerwa J, Krebs T, Lim F, Chang C-Y, McDonnell DP. Estrogen Receptor Signaling in the Immune System. Endocr Rev. 2023 Jan 12;44(1):117–41.
Chakraborty, Binita, et al. “Estrogen Receptor Signaling in the Immune System.Endocr Rev, vol. 44, no. 1, Jan. 2023, pp. 117–41. Pubmed, doi:10.1210/endrev/bnac017.
Chakraborty B, Byemerwa J, Krebs T, Lim F, Chang C-Y, McDonnell DP. Estrogen Receptor Signaling in the Immune System. Endocr Rev. 2023 Jan 12;44(1):117–141.
Journal cover image

Published In

Endocr Rev

DOI

EISSN

1945-7189

Publication Date

January 12, 2023

Volume

44

Issue

1

Start / End Page

117 / 141

Location

United States

Related Subject Headings

  • Selective Estrogen Receptor Modulators
  • Receptors, Estrogen
  • Male
  • Immune System
  • Humans
  • Female
  • Estrogens
  • Estrogen Receptor beta
  • Estrogen Receptor alpha
  • Estradiol