Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Magic angle effect on diffusion tensor imaging in ligament and brain.

Publication ,  Journal Article
Wang, N; Wen, Q; Maharjan, S; Mirando, AJ; Qi, Y; Hilton, MJ; Spritzer, CE
Published in: Magn Reson Imaging
October 2022

PURPOSE: To evaluate the magic angle effect on diffusion tensor imaging (DTI) measurements in rat ligaments and mouse brains. METHODS: Three rat knee joints and three mouse brains were scanned at 9.4 T using a modified 3D diffusion-weighted spin echo pulse sequence with the isotropic spatial resolution of 45 μm. The b value was 1000 s/mm2 for rat knee and 4000 s/mm2 for mouse brain. DTI model was used to investigate the quantitative metrics at different orientations with respect to the main magnetic field. The collagen fiber structure of the ligament was validated with polarized light microscopy (PLM) imaging. RESULTS: The signal intensity, signal-to-noise ratio (SNR), and DTI metrics in the ligament were strongly dependent on the collagen fiber orientation with respect to the main magnetic field from both simulation and actual MRI scans. The variation of fractional anisotropy (FA) was about ~32%, and the variation of mean diffusivity (MD) was ~11%. These findings were further validated with the numerical simulation at different SNRs (~10.0 to 86.0). Compared to the ligament, the DTI metrics showed little orientation dependence in mouse brains. CONCLUSION: Magic angle effect plays an important role in DTI measurements in the highly ordered collagen-rich tissues, while MD showed less orientation dependence than FA.

Duke Scholars

Published In

Magn Reson Imaging

DOI

EISSN

1873-5894

Publication Date

October 2022

Volume

92

Start / End Page

243 / 250

Location

Netherlands

Related Subject Headings

  • Rats
  • Nuclear Medicine & Medical Imaging
  • Mice
  • Ligaments
  • Diffusion Tensor Imaging
  • Collagen
  • Brain
  • Anisotropy
  • Animals
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wang, N., Wen, Q., Maharjan, S., Mirando, A. J., Qi, Y., Hilton, M. J., & Spritzer, C. E. (2022). Magic angle effect on diffusion tensor imaging in ligament and brain. Magn Reson Imaging, 92, 243–250. https://doi.org/10.1016/j.mri.2022.06.008
Wang, Nian, Qiuting Wen, Surendra Maharjan, Anthony J. Mirando, Yi Qi, Matthew J. Hilton, and Charles E. Spritzer. “Magic angle effect on diffusion tensor imaging in ligament and brain.Magn Reson Imaging 92 (October 2022): 243–50. https://doi.org/10.1016/j.mri.2022.06.008.
Wang N, Wen Q, Maharjan S, Mirando AJ, Qi Y, Hilton MJ, et al. Magic angle effect on diffusion tensor imaging in ligament and brain. Magn Reson Imaging. 2022 Oct;92:243–50.
Wang, Nian, et al. “Magic angle effect on diffusion tensor imaging in ligament and brain.Magn Reson Imaging, vol. 92, Oct. 2022, pp. 243–50. Pubmed, doi:10.1016/j.mri.2022.06.008.
Wang N, Wen Q, Maharjan S, Mirando AJ, Qi Y, Hilton MJ, Spritzer CE. Magic angle effect on diffusion tensor imaging in ligament and brain. Magn Reson Imaging. 2022 Oct;92:243–250.
Journal cover image

Published In

Magn Reson Imaging

DOI

EISSN

1873-5894

Publication Date

October 2022

Volume

92

Start / End Page

243 / 250

Location

Netherlands

Related Subject Headings

  • Rats
  • Nuclear Medicine & Medical Imaging
  • Mice
  • Ligaments
  • Diffusion Tensor Imaging
  • Collagen
  • Brain
  • Anisotropy
  • Animals
  • 3202 Clinical sciences