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Functional consequences of allotypic polymorphisms in human immunoglobulin G subclasses.

Publication ,  Journal Article
Crowley, AR; Richardson, SI; Tuyishime, M; Jennewein, M; Bailey, MJ; Lee, J; Alter, G; Ferrari, G; Morris, L; Ackerman, ME
Published in: Immunogenetics
February 2023

Heritable polymorphisms within the human IgG locus, collectively termed allotypes, have often been linked by statistical associations, but rarely mechanistically, to a wide range of disease states. One potential explanation for these associations is that IgG allotype alters host cell receptors' affinity for IgG, dampening or enhancing an immune response depending on the nature of the change and the receptors. In this work, a panel of allotypic antibody variants were evaluated using multiplexed, label-free biophysical methods and cell-based functional assays to determine what effect, if any, human IgG polymorphisms have on antibody function. While we observed several differences in FcγR affinity among allotypes, there was little evidence of dramatically altered FcγR-based effector function or antigen recognition activity associated with this aspect of genetic variability.

Duke Scholars

Published In

Immunogenetics

DOI

EISSN

1432-1211

Publication Date

February 2023

Volume

75

Issue

1

Start / End Page

1 / 16

Location

United States

Related Subject Headings

  • Receptors, IgG
  • Immunology
  • Immunoglobulin G
  • Immunoglobulin Allotypes
  • Immunity
  • Humans
  • 3204 Immunology
  • 1107 Immunology
 

Citation

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Crowley, A. R., Richardson, S. I., Tuyishime, M., Jennewein, M., Bailey, M. J., Lee, J., … Ackerman, M. E. (2023). Functional consequences of allotypic polymorphisms in human immunoglobulin G subclasses. Immunogenetics, 75(1), 1–16. https://doi.org/10.1007/s00251-022-01272-7
Crowley, Andrew R., Simone I. Richardson, Marina Tuyishime, Madeleine Jennewein, Meredith J. Bailey, Jiwon Lee, Galit Alter, Guido Ferrari, Lynn Morris, and Margaret E. Ackerman. “Functional consequences of allotypic polymorphisms in human immunoglobulin G subclasses.Immunogenetics 75, no. 1 (February 2023): 1–16. https://doi.org/10.1007/s00251-022-01272-7.
Crowley AR, Richardson SI, Tuyishime M, Jennewein M, Bailey MJ, Lee J, et al. Functional consequences of allotypic polymorphisms in human immunoglobulin G subclasses. Immunogenetics. 2023 Feb;75(1):1–16.
Crowley, Andrew R., et al. “Functional consequences of allotypic polymorphisms in human immunoglobulin G subclasses.Immunogenetics, vol. 75, no. 1, Feb. 2023, pp. 1–16. Pubmed, doi:10.1007/s00251-022-01272-7.
Crowley AR, Richardson SI, Tuyishime M, Jennewein M, Bailey MJ, Lee J, Alter G, Ferrari G, Morris L, Ackerman ME. Functional consequences of allotypic polymorphisms in human immunoglobulin G subclasses. Immunogenetics. 2023 Feb;75(1):1–16.
Journal cover image

Published In

Immunogenetics

DOI

EISSN

1432-1211

Publication Date

February 2023

Volume

75

Issue

1

Start / End Page

1 / 16

Location

United States

Related Subject Headings

  • Receptors, IgG
  • Immunology
  • Immunoglobulin G
  • Immunoglobulin Allotypes
  • Immunity
  • Humans
  • 3204 Immunology
  • 1107 Immunology