Skip to main content

Actions of Dendritic Cells in the Kidney during Hypertension.

Publication ,  Journal Article
Lu, X; Crowley, SD
Published in: Compr Physiol
August 11, 2022

The immune response plays a critical role in the pathogenesis of hypertension, and immune cell populations can promote blood pressure elevation via actions in the kidney. Among these cell lineages, dendritic cells (DCs), the most potent antigen-presenting cells, play a central role in regulating immune response during hypertension and kidney disease. DCs have different subtypes, and renal DCs are comprised of the CD103+ CD11b- and CD103- CD11b+ subsets. DCs become mature and express costimulatory molecules on their surface once they encounter antigen. Isolevuglandin-modified proteins function as antigens to activate DCs and trigger them to stimulate T cells. Activated T cells accumulate in the hypertensive kidney, release effector cytokines, promote renal oxidative stress, and promote renal salt and water retention. Individual subsets of activated T cells can secrete tumor necrosis factor-alpha, interleukin-17A, and interferon-gamma, each of which has augmented the elevation of blood pressure in hypertensive models by enhancing renal sodium transport. Fms-like tyrosine kinase 3 ligand-dependent classical DCs are required to sustain the full hypertensive response, but C-X3 -C chemokine receptor 1 positive DCs do not regulate blood pressure. Excess sodium enters the DC through transporters to activate DCs, whereas the ubiquitin editor A20 in dendritic cells constrains blood pressure elevation by limiting T cell activation. By contrast, activation of the salt sensing kinase, serum/glucocorticoid kinase 1 in DCs exacerbates salt-sensitive hypertension. This article discusses recent studies illustrating mechanisms through which DC-T cell interactions modulate levels of pro-hypertensive mediators to regulate blood pressure via actions in the kidney. © 2022 American Physiological Society. Compr Physiol 12:1-15, 2022.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Compr Physiol

DOI

EISSN

2040-4603

Publication Date

August 11, 2022

Volume

12

Issue

3

Start / End Page

4087 / 4101

Location

United States

Related Subject Headings

  • Sodium
  • Kidney
  • Hypertension
  • Humans
  • Dendritic Cells
  • Blood Pressure
  • 3208 Medical physiology
  • 3109 Zoology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lu, X., & Crowley, S. D. (2022). Actions of Dendritic Cells in the Kidney during Hypertension. Compr Physiol, 12(3), 4087–4101. https://doi.org/10.1002/cphy.c210050
Lu, Xiaohan, and Steven D. Crowley. “Actions of Dendritic Cells in the Kidney during Hypertension.Compr Physiol 12, no. 3 (August 11, 2022): 4087–4101. https://doi.org/10.1002/cphy.c210050.
Lu X, Crowley SD. Actions of Dendritic Cells in the Kidney during Hypertension. Compr Physiol. 2022 Aug 11;12(3):4087–101.
Lu, Xiaohan, and Steven D. Crowley. “Actions of Dendritic Cells in the Kidney during Hypertension.Compr Physiol, vol. 12, no. 3, Aug. 2022, pp. 4087–101. Pubmed, doi:10.1002/cphy.c210050.
Lu X, Crowley SD. Actions of Dendritic Cells in the Kidney during Hypertension. Compr Physiol. 2022 Aug 11;12(3):4087–4101.

Published In

Compr Physiol

DOI

EISSN

2040-4603

Publication Date

August 11, 2022

Volume

12

Issue

3

Start / End Page

4087 / 4101

Location

United States

Related Subject Headings

  • Sodium
  • Kidney
  • Hypertension
  • Humans
  • Dendritic Cells
  • Blood Pressure
  • 3208 Medical physiology
  • 3109 Zoology