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Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals.

Publication ,  Journal Article
Tahir, UA; Katz, DH; Avila-Pachecho, J; Bick, AG; Pampana, A; Robbins, JM; Yu, Z; Chen, Z-Z; Benson, MD; Cruz, DE; Ngo, D; Deng, S; Shi, X ...
Published in: Nat Commun
August 22, 2022

Integrating genetic information with metabolomics has provided new insights into genes affecting human metabolism. However, gene-metabolite integration has been primarily studied in individuals of European Ancestry, limiting the opportunity to leverage genomic diversity for discovery. In addition, these analyses have principally involved known metabolites, with the majority of the profiled peaks left unannotated. Here, we perform a whole genome association study of 2,291 metabolite peaks (known and unknown features) in 2,466 Black individuals from the Jackson Heart Study. We identify 519 locus-metabolite associations for 427 metabolite peaks and validate our findings in two multi-ethnic cohorts. A significant proportion of these associations are in ancestry specific alleles including findings in APOE, TTR and CD36. We leverage tandem mass spectrometry to annotate unknown metabolites, providing new insight into hereditary diseases including transthyretin amyloidosis and sickle cell disease. Our integrative omics approach leverages genomic diversity to provide novel insights into diverse cardiometabolic diseases.

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Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

August 22, 2022

Volume

13

Issue

1

Start / End Page

4923

Location

England

Related Subject Headings

  • Tandem Mass Spectrometry
  • Metabolomics
  • Metabolome
  • Humans
  • Genome-Wide Association Study
  • Cardiovascular Diseases
  • Black People
 

Citation

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Chicago
ICMJE
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Tahir, U. A., Katz, D. H., Avila-Pachecho, J., Bick, A. G., Pampana, A., Robbins, J. M., … Gerszten, R. E. (2022). Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals. Nat Commun, 13(1), 4923. https://doi.org/10.1038/s41467-022-32275-3
Tahir, Usman A., Daniel H. Katz, Julian Avila-Pachecho, Alexander G. Bick, Akhil Pampana, Jeremy M. Robbins, Zhi Yu, et al. “Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals.Nat Commun 13, no. 1 (August 22, 2022): 4923. https://doi.org/10.1038/s41467-022-32275-3.
Tahir UA, Katz DH, Avila-Pachecho J, Bick AG, Pampana A, Robbins JM, et al. Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals. Nat Commun. 2022 Aug 22;13(1):4923.
Tahir, Usman A., et al. “Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals.Nat Commun, vol. 13, no. 1, Aug. 2022, p. 4923. Pubmed, doi:10.1038/s41467-022-32275-3.
Tahir UA, Katz DH, Avila-Pachecho J, Bick AG, Pampana A, Robbins JM, Yu Z, Chen Z-Z, Benson MD, Cruz DE, Ngo D, Deng S, Shi X, Zheng S, Eisman AS, Farrell L, Hall ME, Correa A, Tracy RP, Durda P, Taylor KD, Liu Y, Johnson WC, Guo X, Yao J, Chen Y-DI, Manichaikul AW, Ruberg FL, Blaner WS, Jain D, NHLBI Trans-Omics for Precision Medicine 1 Consortium, Bouchard C, Sarzynski MA, Rich SS, Rotter JI, Wang TJ, Wilson JG, Clish CB, Natarajan P, Gerszten RE. Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals. Nat Commun. 2022 Aug 22;13(1):4923.

Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

August 22, 2022

Volume

13

Issue

1

Start / End Page

4923

Location

England

Related Subject Headings

  • Tandem Mass Spectrometry
  • Metabolomics
  • Metabolome
  • Humans
  • Genome-Wide Association Study
  • Cardiovascular Diseases
  • Black People