Eradicating Atherosclerosis: Should We Start Statins at Younger Ages and at Lower LDL-Cs.

PURPOSE OF REVIEW: Given the increasing burden of cardiovascular disease, we review the literature for earlier initiation of statin therapy at younger ages and lower low-density lipoprotein cholesterol (LDL-C) levels, with the goal of preventing the development of atherosclerosis prior to clinical events. RECENT FINDINGS: There is a rising prevalence of dyslipidemia among younger adults. Although guidelines offer recommendations for adults over 40, there is little guidance for the management of younger adults with moderately elevated LDL-C levels. Earlier and more aggressive statin use may slow progression, or even halt atherosclerosis, and may likewise be beneficial and cost-effective on a population level. Further research is needed to define the exact age and LDL-C level at which to start statin therapy. Until then, more detailed risk stratification with lab testing and imaging should be used to identify younger adults at the highest risk.

Duke Scholars

Author Robert W. McGarrah III Medicine, Cardiology

Author Nishant Shah Medicine, Cardiology

Author Michelle Diane Kelsey Medicine, Cardiology

Author Thomas Michael O'Toole Medicine, Medical Oncology

Author Neha Pagidipati Medicine, Cardiology